ID A0A1U7RTB5_ALLSI Unreviewed; 373 AA.
AC A0A1U7RTB5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Embryonic growth/differentiation factor 1 {ECO:0000313|RefSeq:XP_006028903.1};
GN Name=GDF1 {ECO:0000313|RefSeq:XP_006028903.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006028903.1};
RN [1] {ECO:0000313|RefSeq:XP_006028903.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_006028903.1; XM_006028841.3.
DR AlphaFoldDB; A0A1U7RTB5; -.
DR STRING; 38654.A0A1U7RTB5; -.
DR GeneID; 102375970; -.
DR KEGG; asn:102375970; -.
DR CTD; 2657; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; A0A1U7RTB5; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF151; EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 256..373
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 373 AA; 41420 MW; 76DCFF98CCE1E752 CRC64;
MRLVSWRAVF AAGLFWALIS GTLGMDLSTR ESLLLKSLGL SAKPSPRSPA PVPSVLWRIF
QKREIPSPWS PGQEDACRVE EFNVPGNIVR VFSDQGHFLH SGGPRTLLCL EKHLYFTLSV
LEDGEQLTMA QLQLQFGHNS YRAPGPGQVF ELRLYRAPPP SLRELPSPAA RRRLLLAQSF
AQLHKLLLFN LTQVGRDWRT PSRNLGLVLE ISVSSGTGSS ALLGRPPGNF CAGADSFLDA
SLLVVSLQPG QCKASRKKRS SYYAPVMPSS LCKPRRLYIS FSDVGWENWI IAPQGYMANY
CLGECPFPLT TELNSTNHAI LQTMVHSLDP EGTPQPCCVP VRLSPISVLF YDNHDNVVLR
HYEDMVVDEC GCR
//
