ID   A0A1U7RWL6_ALLSI        Unreviewed;       526 AA.
AC   A0A1U7RWL6;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Cytochrome P450 1A {ECO:0000256|RuleBase:RU368045};
DE            EC=1.14.14.1 {ECO:0000256|RuleBase:RU368045};
GN   Name=LOC102379827 {ECO:0000313|RefSeq:XP_006020343.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006020343.1};
RN   [1] {ECO:0000313|RefSeq:XP_006020343.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       They oxidize a variety of structurally unrelated compounds, including
CC       steroids, fatty acids, and xenobiotics.
CC       {ECO:0000256|RuleBase:RU368045}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|RuleBase:RU368045};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU368045}. Microsome membrane
CC       {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU368045}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   RefSeq; XP_006020343.1; XM_006020281.3.
DR   AlphaFoldDB; A0A1U7RWL6; -.
DR   GeneID; 102379827; -.
DR   OrthoDB; 2900138at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd20676; CYP1A; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24289:SF18; CYTOCHROME P450 1A2; 1.
DR   PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01683; EP450ICYP1A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU368045};
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000461};
KW   Microsome {ECO:0000256|ARBA:ARBA00022848, ECO:0000256|RuleBase:RU368045};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   526 AA;  60418 MW;  9886E9469423481B CRC64;
     MKTAMSLLGS QGIFSVTEIL IVLAVFFLMF TVIRSFQQQI PYGLKRLPEP RGYPLIGNVL
     ELGRNPHLSL TQMSQKYGDV MQIRIGTRPV LVLSGLNTIR QALVKQAEDF MGRPDLCSFR
     HIGNGQSLTF GPDSGEVWRA RRKVAQNALK TFSVSPSPTA SSTCLLEEHV FKEADYLITK
     LLQQMKEEKS FDAYRYTVIS VANVICGMCF GKRYTHDDQE LLSLVNLSNE FGDVAASGNP
     ADFIPILQYF PSRTMKIFKD LNKRFSSFVH KIVKEHYTTF DKSHIRDITD SLIEHCQDKK
     IDVNANIQLP EEKIVNLVND LFGAGFDTVT TALSWSLVYI VTYPDIQKKI QNELDQTIGR
     ERRPRLSDRL MLPYTEAFIL ETFRHSSFMP FTIPHCTTKD TSLNGYYIPK NLCVFINQWQ
     VNHDETLWKE PSAFNPERFL NAEGTEINRV ESDKVMIFGL GKRRCIGESI ARWEIFLFLA
     TLLQQLEFSV CDGQKVDITP QYGLTMKNEK YEYFQIKQRF PNKSFE
//