ID A0A1U7RWQ4_ALLSI Unreviewed; 914 AA.
AC A0A1U7RWQ4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Sodium/calcium exchanger 3 isoform X4 {ECO:0000313|RefSeq:XP_006025242.2};
GN Name=SLC8A3 {ECO:0000313|RefSeq:XP_006025242.2};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006025242.2};
RN [1] {ECO:0000313|RefSeq:XP_006025242.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR RefSeq; XP_006025242.2; XM_006025180.2.
DR AlphaFoldDB; A0A1U7RWQ4; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF7; SODIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 384..484
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 513..613
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 914 AA; 101575 MW; 4D2DD0CABC8602EF CRC64;
MALLRLQPLT SAFLHFGLVT FVLFLHGLQV DAGLTGDSPN IGQNNSCAGS FDCKEGVILP
IWYPENPSLG DKIARVIVYF VALIYMFLGV SIIADRFMAS IEVITSQEKE ITIKKPNGET
TTTTIRIWNE TVSNLTLMAL GSSAPEILLS LIEVCGHGFI AGDLGPSTIV GSAAFNMFII
IAICVYVIPD GETRKIKHLR VFFVTAAWSI FAYIWLYMIL AVFSPGVVQV WEGLLTLFFF
PLCVLLAWVA DRRLLFYKYM HKRYRTDKHR GIIIESEGDH TKGIEMDGKM MNSHFLDGNL
VTMEGKEVDE SRKEMIRILK DLKQKHPEKD LDQLVEMANY YALSHQQKSR AFYRIQATRM
MTGAGNILKK HAAEQAKKST SLHEICPEEP EEFISRVCFD PCSYQCLENC GAVLLTVVRK
GGDISKTIYV DYKTEDGSAN AGADYEFTEG TVVLKSGETQ KEFSVGIIDD DIFEEDEHFF
VRLSNLRVVE MEETPELNSS PYPKAILSSP CVATVTILDD DHAGIFTFEC DVIHVSESIG
VMEVKVLRTS GARGTVIVPF RTVEGTAKGG GEDFEDTFGE LEFKNDETVK TVRVKIVDEE
EYERQENFFI ALGEPKWMER GISVADRKLT VEEEEAKRIA EMGKPVLGEH PKLEVIIEES
YEFKSTVDKL IKKTNLALVV GTHSWRDQFM EAITVSAAGD EDEDESGEER LPSCFDYVMH
FLTVFWKVLF ACVPPTEYCN GWACFVVSIM IIGMLTAVIG DLASHFGCTI GLKDSVTAVV
FVAFGTSVPD TFASKAAATQ DVYADASIGN VTGSNAVNVF LGIGLAWSVA AIYWASQGQE
FHVSAGTLAF SVTLFTIFAF ICISILLYRR RPHLGGELGG PKGCKLATTL LLVSLWLLYI
LFATLEAYCY IKGF
//
