ID A0A1U7RZM4_ALLSI Unreviewed; 470 AA.
AC A0A1U7RZM4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Platelet glycoprotein 4 {ECO:0000256|ARBA:ARBA00020772};
DE AltName: Full=Glycoprotein IIIb {ECO:0000256|ARBA:ARBA00032780};
DE AltName: Full=PAS IV {ECO:0000256|ARBA:ARBA00031821};
DE AltName: Full=PAS-4 {ECO:0000256|ARBA:ARBA00032188};
DE AltName: Full=Platelet glycoprotein IV {ECO:0000256|ARBA:ARBA00029966};
GN Name=CD36 {ECO:0000313|RefSeq:XP_006026688.1,
GN ECO:0000313|RefSeq:XP_014376782.1, ECO:0000313|RefSeq:XP_025063388.1,
GN ECO:0000313|RefSeq:XP_025063389.1, ECO:0000313|RefSeq:XP_025063390.1,
GN ECO:0000313|RefSeq:XP_025063391.1, ECO:0000313|RefSeq:XP_025063392.1,
GN ECO:0000313|RefSeq:XP_025063393.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006026688.1};
RN [1] {ECO:0000313|RefSeq:XP_006026688.1, ECO:0000313|RefSeq:XP_014376782.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in);
CC Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823;
CC Evidence={ECO:0000256|ARBA:ARBA00000626};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33656;
CC Evidence={ECO:0000256|ARBA:ARBA00000626};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-
CC octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245;
CC Evidence={ECO:0000256|ARBA:ARBA00000542};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45265;
CC Evidence={ECO:0000256|ARBA:ARBA00000542};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248,
CC ChEBI:CHEBI:17968; Evidence={ECO:0000256|ARBA:ARBA00001892};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45249;
CC Evidence={ECO:0000256|ARBA:ARBA00001892};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256,
CC ChEBI:CHEBI:7896; Evidence={ECO:0000256|ARBA:ARBA00000934};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45257;
CC Evidence={ECO:0000256|ARBA:ARBA00000934};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=tetracosanoate(out) = tetracosanoate(in);
CC Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014;
CC Evidence={ECO:0000256|ARBA:ARBA00023949};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45261;
CC Evidence={ECO:0000256|ARBA:ARBA00023949};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=tetradecanoate(out) = tetradecanoate(in);
CC Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807;
CC Evidence={ECO:0000256|ARBA:ARBA00000996};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45253;
CC Evidence={ECO:0000256|ARBA:ARBA00000996};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}.
CC -!- SIMILARITY: Belongs to the CD36 family.
CC {ECO:0000256|ARBA:ARBA00010532}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006026688.1; XM_006026626.2.
DR RefSeq; XP_014376782.1; XM_014521296.2.
DR RefSeq; XP_025063388.1; XM_025207603.1.
DR RefSeq; XP_025063389.1; XM_025207604.1.
DR RefSeq; XP_025063390.1; XM_025207605.1.
DR RefSeq; XP_025063391.1; XM_025207606.1.
DR RefSeq; XP_025063392.1; XM_025207607.1.
DR RefSeq; XP_025063393.1; XM_025207608.1.
DR STRING; 38654.A0A1U7RZM4; -.
DR GeneID; 102384601; -.
DR KEGG; asn:102384601; -.
DR CTD; 948; -.
DR eggNOG; KOG3776; Eukaryota.
DR OrthoDB; 315994at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR005428; CD36/SCARB1/SNMP1.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923:SF12; PLATELET GLYCOPROTEIN 4; 1.
DR PANTHER; PTHR11923; SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01610; CD36ANTIGEN.
DR PRINTS; PR01609; CD36FAMILY.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR605428-52};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DISULFID 241..309
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
FT DISULFID 270..331
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
FT DISULFID 311..320
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
SQ SEQUENCE 470 AA; 52493 MW; 5A2A43C35A0E004D CRC64;
MGCNRNCGLL TGAIIGAVLA IFGGVLIPLG DYFITSTIKK EVVIENGTIA YENWIVPGSP
VYRQFWIFDV QNPAEVMNGS QPILQQKGPY TYRVRYFPKI NITQNPDHTV SYMLPNTARF
EPTMSAGTEN DTVTCINLAV VAAPALYTNT FIQLLLNTWI KASNSAMLQN RTVKEILWGY
KDPFLEKVPF PLDSTLGVFY PYNGTSDGSY RVYNGKDDIS KTAIIDSYKN KRNLSYWEGH
CDLVNGTDGS SFPPFVKKDS VLRFFSSDIC RSIYGIFTSD QVVKGIRLYR FTVPSAAFAS
PLVNPDNLCF CTDRGISNNC TSAGALDISS CKAGRPVFIT LPHFLFASDD IKENIEGLSP
NKDEHETFLD VEPTTGFTLH FAKRLQVNLL VKPAPKITAL SKVKKPYIFP LLWLNETAII
GDDKAEMFRS KVTSRINMLN ILQIGLIIAG SVMFLAFMIS YFVYRSKKLK
//
