ID A0A1U7S046_ALLSI Unreviewed; 1284 AA.
AC A0A1U7S046;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRJ {ECO:0000313|RefSeq:XP_006022078.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006022078.1};
RN [1] {ECO:0000313|RefSeq:XP_006022078.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_006022078.1; XM_006022016.3.
DR GeneID; 102384685; -.
DR CTD; 5795; -.
DR OrthoDB; 5399547at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 6.
DR CDD; cd14615; R-PTPc-J; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_006022078.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1284
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010570244"
FT TRANSMEM 919..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..219
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 220..308
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 309..397
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 398..488
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 489..579
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 580..672
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 988..1245
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1163..1236
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 41..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 142646 MW; 1CA247DBAFF41925 CRC64;
MEQPFFPSLL LLLLLSLSKI KSSNGCGPNC SSIITTTTRK LSSKELTEGS VTHGDGMSFS
SLSTSEPTSV SSTHFASIAD FLESNSGTDS MKQNVSLSGK HNSTDNETST ASPDSTLLNN
GTGSSDPKPS PVFDIQAIAI STDKVNLTWK NNDTSADNYT YVILKAGTEF PNITVLQKMQ
AVIMGLEPGT LYNFTIYPVA PGSTTEGDRN STTVYTKPSP VFDIQAIDIS TDYVNLTWKN
NDLAADNYSY MILGDSASFP NITIFEKRQA VITGLKPGTL YNITIYPLAP DNATKGDGNS
TTVYTKPSPV FDIQAIDIST DYVNLTWKNN DSDADNYTYM ILGNSASFPN STIFQKRQAV
ITGLEPGTLY NITIYPLAPD NATKGDGNST IVYTKPSPVF AVQAIHISTD QVNLTWKNND
AAADKYTYEI KFFKDGNLTL WPEKPQITGA VITGLEPGTL YNFTIYPLAP DNTTRGDGNS
TSVYTKPSPV FAVQAIHIST DQVNLTWKNN DAAADKYTYE IQFFKDGNLT FWPEKPQITG
AVITGLEPGT LYNFTIYPLA PDNTTRGDGN STSVYTEPSP VFDIQAIDIS TDYVNLTWKN
DDSAADNYIY VIEIFKHGTL FPSNKTLPKR EAVITGLEPG TSYHFKVFPL ALDNRTWGYP
NSTSVCTNAA PPHEFKCEQV PRKPELKLNW LCPLGNNSGF RIKISNGIRT NESSVSSCKS
GNVEKSIDNL TYYTTFYINI TTHSCGKDSL PEQRTCATSI TDPPAPSAPP AITGIDHNSF
KVQFSPFKSE HGPLKAYAVL ITTANDNQPS KYNLNLTYHD FKTKKTHTYV TYVMNIEHTR
ASLSTSRSQP YTVVVGNANT THAYYNGPLE PLGLYRTSVA GFTDITYANN KTGPIVEERS
YVSFTPYSEP FRVPQDPGVI VGAVLGSILC VSAVLLVVVF VFWRRRRKDG KNNDVSFSQI
KPKKSKPIKV ENFESYFKTQ QADSNCGFAE EYEELRPAGV HQPKFAAELA ENRGKNRYNN
VLPYDISRVK LSAQSHPTDD YINANYMPGY NLRKEFIAAQ GPLPNTLEDF WRMIWEKNIY
AIVMLTKCIE QGRTKCEQYW ADKQPMSYGD ITVTMTSEIV LAEWTIRDFT IEDNNETDSH
CVRQFHFTAW PDHGVPETTE LLISFRHLVE EYARQNPPES PTLVHCSAGV GRTGTFIAID
RLIQQIEMEN TADVYGVVYD LRMHRPLMVQ TEEQYVFLNQ CVLDIIKSQR DKKVDLIYQN
TTAMAIYENL APAPNFGKAN GYCA
//
