ID A0A1U7S1F5_ALLSI Unreviewed; 193 AA.
AC A0A1U7S1F5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Copper transport protein {ECO:0000256|RuleBase:RU367022};
GN Name=SLC31A1 {ECO:0000313|RefSeq:XP_006022725.1,
GN ECO:0000313|RefSeq:XP_006022727.1, ECO:0000313|RefSeq:XP_025058836.1,
GN ECO:0000313|RefSeq:XP_025058838.1, ECO:0000313|RefSeq:XP_025058839.1,
GN ECO:0000313|RefSeq:XP_025058840.1, ECO:0000313|RefSeq:XP_025058841.1,
GN ECO:0000313|RefSeq:XP_025058842.1, ECO:0000313|RefSeq:XP_025058843.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025058843.1};
RN [1] {ECO:0000313|RefSeq:XP_006022725.1, ECO:0000313|RefSeq:XP_006022727.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mobilizes copper(1+) out of the endosomal compartment, making
CC copper(1+) available for export out of the cells.
CC {ECO:0000256|ARBA:ARBA00037299}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ag(+)(out) = Ag(+)(in); Xref=Rhea:RHEA:75207,
CC ChEBI:CHEBI:49468; Evidence={ECO:0000256|ARBA:ARBA00036430};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cu(+)(out) = Cu(+)(in); Xref=Rhea:RHEA:75211,
CC ChEBI:CHEBI:49552; Evidence={ECO:0000256|ARBA:ARBA00036192};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early
CC endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004520}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC {ECO:0000256|RuleBase:RU367022}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU367022}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000256|RuleBase:RU367022}.
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DR RefSeq; XP_006022725.1; XM_006022663.3.
DR RefSeq; XP_006022727.1; XM_006022665.3.
DR RefSeq; XP_006022728.1; XM_006022666.2.
DR RefSeq; XP_014374976.1; XM_014519490.1.
DR RefSeq; XP_025058836.1; XM_025203051.1.
DR RefSeq; XP_025058838.1; XM_025203053.1.
DR RefSeq; XP_025058839.1; XM_025203054.1.
DR RefSeq; XP_025058840.1; XM_025203055.1.
DR RefSeq; XP_025058841.1; XM_025203056.1.
DR RefSeq; XP_025058842.1; XM_025203057.1.
DR RefSeq; XP_025058843.1; XM_025203058.1.
DR GeneID; 102378049; -.
DR CTD; 1317; -.
DR OrthoDB; 3399710at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483:SF22; HIGH AFFINITY COPPER UPTAKE PROTEIN 1; 1.
DR PANTHER; PTHR12483; SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS; 1.
DR Pfam; PF04145; Ctr; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Copper {ECO:0000256|RuleBase:RU367022};
KW Copper transport {ECO:0000256|RuleBase:RU367022};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion transport {ECO:0000256|RuleBase:RU367022};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367022};
KW Oxidation {ECO:0000256|ARBA:ARBA00023097};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367022};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367022}; Transport {ECO:0000256|RuleBase:RU367022}.
FT TRANSMEM 72..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367022"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 193 AA; 21600 MW; 274D1C63CE1B11D2 CRC64;
MSLSHHADHM NHTMSGTMPS SVHPPEHYHP TTSPGHNHEG GMMMMMDMTF HFSYKNVPLL
FSGLVINTPG EMAGAFVAVF FLAMFYEGLK IARECLLRKS QVSIRYNSMP VPGPNGTILM
ETHKTVGQQM LSFPHLLQTV LHIIQVVVSY FLMLIFMTYN GYLCIAVAAG AGTGYFFFSW
KKAVVVDITE HCH
//
