ID A0A1U7S5T4_ALLSI Unreviewed; 1071 AA.
AC A0A1U7S5T4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=LOW QUALITY PROTEIN: integrin alpha-8 {ECO:0000313|RefSeq:XP_006031759.2};
GN Name=ITGA8 {ECO:0000313|RefSeq:XP_006031759.2};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006031759.2};
RN [1] {ECO:0000313|RefSeq:XP_006031759.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_006031759.2; XM_006031697.3.
DR AlphaFoldDB; A0A1U7S5T4; -.
DR STRING; 38654.A0A1U7S5T4; -.
DR KEGG; asn:102385374; -.
DR eggNOG; KOG3637; Eukaryota.
DR InParanoid; A0A1U7S5T4; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 6.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1016..1042
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 54..117
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 131..192
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 197..249
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 316..381
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 382..440
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 444..507
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 492..648
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 650..790
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 796..1009
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 119123 MW; 313EDB92335942AC CRC64;
MRERRHHSPP QGSPSAAARS RSRSRSRTMR MRMLLTLLLP GMLWPRGLLA FNLDEEQRSV
YSGPQGSYFG YAVDFYIPEP GTVSVLVGAP KANTTQPEIQ EGGAVYYCPW PAAQCKQIPF
DTTNNRKIKV NGTREPIEFK SNQWFGATVK AHKSKVVACA PLYHWRTLKA TPEKDPVGTC
YVAIQNFSAY AEYSPCRNSN ADPEGQGFCQ AGFSLDFYKN GDLIVGGPGS FYWQGQVITA
NIADIITDYS FKDILRKLIR EKQTGVAPPS YDDNYLGYSV AAGEFTGDSE QELVVGVPRG
AQNFGYVSII NSTDLTFIQN FTGEQMASYF GYTVAVSDVN NDGLDDILVG APLFMEREFE
SKPKEVGQVY LYLQESAFYF QDAQILSGTD MFGRFGSAIA HLGDLNQDGY NDIAIGAPFA
GEDRGGKVLV YNGHSNGLNA KPSQVLSGFW ASQSMPAGFG FTLRGDSDVD KNDYPDLIVG
AFGAGKVVVY RARPVVTVDA QLLLNPMIVN PENKTCQLPS SRILVACFTV RVCAAFEGQS
ISDKIALKAE LQLDSLKQKG AVKRTLFFDY HQSHHLFPIV IERQKRLHCQ DFVVYLRDET
EFRDKLSPIS VSLNYSLDES TSVDSLAVKP ILNYYQESTV TEQAYILVDC GEDNLCIPDL
KLSATPDKDQ LIIGEENCVV LLIHPRNDGE GAYEAELHIK IPPEADYTGV ERNNKALRVL
SCDYKMENET RMVVCDLGNP MVAGTNFSTG IRFSVQHFEN ADFSIKFELQ VKSSNKVNSS
SNLVNLQINI SAVAQVQIRG VSNPPQIVLP LHNWKPKDEP TKEDDLGPLV EHIYELHNIG
PGAINDTLLH VGWPVSSREE FLLYILHIQT HGPLQCQTSS AINELQIKFA IQEDTPELTA
FLRNSTIPHY IRRRDIKVAE PQRRSSSKIL NCTNVKCLII SCIVGQLDRG TSAALKIRSR
LWAQTFLQRK NDHYTLSSNV SFGVKKMPYK VQPAKFPEGS IAIKTSVIWA TPNVSFIIPL
WVIILAILLG LLVLAILTLA LWKCGFFDRA RPPQDDMADR EQLTNDKTTD A
//
