ID A0A1U7S767_ALLSI Unreviewed; 830 AA.
AC A0A1U7S767;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=calcium permeable stress-gated cation channel 1 isoform X1 {ECO:0000313|RefSeq:XP_006036028.2, ECO:0000313|RefSeq:XP_025047961.1};
GN Name=TMEM63C {ECO:0000313|RefSeq:XP_006036028.2,
GN ECO:0000313|RefSeq:XP_025047961.1, ECO:0000313|RefSeq:XP_025047962.1,
GN ECO:0000313|RefSeq:XP_025047963.1, ECO:0000313|RefSeq:XP_025047964.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|RefSeq:XP_006036028.2};
RN [1] {ECO:0000313|RefSeq:XP_006036028.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_006036028.2; XM_006035966.3.
DR RefSeq; XP_025047961.1; XM_025192176.1.
DR RefSeq; XP_025047962.1; XM_025192177.1.
DR RefSeq; XP_025047963.1; XM_025192178.1.
DR RefSeq; XP_025047964.1; XM_025192179.1.
DR STRING; 38654.A0A1U7S767; -.
DR GeneID; 102374023; -.
DR KEGG; asn:102374023; -.
DR CTD; 57156; -.
DR eggNOG; KOG1134; Eukaryota.
DR OrthoDB; 231434at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..222
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 238..416
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 427..685
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 733..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 95061 MW; CB1B73B26155C95C CRC64;
MDSMYFPESA PGGPNPISLD VLSFLDTLAN STEEQCFSAR SHSTVLQGLP FGGVPTVLAI
NFILWLLLLL VFSCLRKAAW DYGRLALLMD NDSLTSLFYG EQSEKEKSPS ETSPLEADNK
DVGFCSWLIS IYQMKDEEIQ SRCGIDATTY LSFQRHLLVL LMIICVLSVA VILPVNFSGD
LLGSNPAHFG RTTIANIPTQ DRLLWLHSIF ALIYFIVTIF SMAHHSVQLE YKANEKVART
LMVTRIPKEI TDPSLIIKHF HEAYPSCTVT NVQFCFDVCK LMKLDAKRRK AMKGRLYFTT
KAQKEGKIMI KTHPCARIFC CRICGFELVD AEQYYGELEE KLTDEFNAER NRITLKRLDM
AFVTFQDERM TAVILKDYSR IHCRKHPQQS SVTTVVKSHC WGVRYAPAPS DIIWENLSVR
GASWWMRFIF LNICLFILLF FLTTPAIIVN TIDMFNVTRP VESLKNPIVT QFFPTLLLWA
FSVFLPFVVY YSAFFESHWT RSNENQLTMH KCYFFLVFMV IILPSLGLTS LDLFFRWLFD
IHFLDEADIK FQCVFLPDNG AFFVNYVITS SLIGTAMELL RIPGLIVYAA RLCFAKSEPE
RLHIKRSQAY EFQFGLEYAW TCCIFAVVMT YSITCPIIVP FGLLYMLLKH MVDRYNIYYV
YIPTKLNQRI HSAAISQVVV APILCMFWLL FFSVLRLGPV RPVTLFTFVV LLFCIIFSFF
GLCLKKLQPR KPSSYQMSEQ SDGAFNDTER SSISSTPNSN MFVATVLQEP ELSLTPAASP
AHQSYGTMGN RLEPAENNEE SGLQSFETEL ETVEGEYRTG PVLENQVRYQ
//
