ID A0A1U7S7M8_ALLSI Unreviewed; 1157 AA.
AC A0A1U7S7M8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Metabotropic glutamate receptor 5 isoform X3 {ECO:0000313|RefSeq:XP_006030622.1};
GN Name=GRM5 {ECO:0000313|RefSeq:XP_006030622.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006030622.1};
RN [1] {ECO:0000313|RefSeq:XP_006030622.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR RefSeq; XP_006030622.1; XM_006030560.1.
DR AlphaFoldDB; A0A1U7S7M8; -.
DR GeneID; 102385450; -.
DR CTD; 2915; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF30; METABOTROPIC GLUTAMATE RECEPTOR 5; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_006030622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1157
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010590105"
FT TRANSMEM 587..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..847
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 876..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 128604 MW; EFDAF63736104F32 CRC64;
MVLLLILAIL LLKEDVNGNF GLLVSAQTNE RRVVAYVPGD IIIGALFSVH HQPTVDKVHE
RKCGEVREQY GIQRVEAMLH TLDRINLDPT LLPNITLGCE IRDSCWHSAV ALEQSIEFIR
DSLISSEEEE GLVRCVDGSS SSFRSKKPIV GVIGPGSSSV AIQVQNLLQL FNIPQIAYSA
TSMDLSDKTL FKYFMRVVPS DAQQARAMVD IVKRYNWTYV SAVHTEGNYG ESGMEAFKDM
SAKEGICIAH SYKIYSNAGE QSFDKLLRKL RSHLPKARVV ACFCEGMTVR GLLMAMRRLG
LAGEFLLLGS DGWADRYDVT DGYQREAVGG ITIKLQSPDV KWFDDYYLQL RPETNHRNPW
FQEFWQHRFQ CQLEGSPQQN YKYNKTCTSE MTLKMQHVQD SKMGFVINAI YSMAYGLHNM
QTALCPGYVG LCDAMKPIDG QKLLDFLMKT NFTGVSGDMI LFDENGDSPG RYEIMNFKKM
GKDYFDYINV GSWDNGELKM DDDEIWSEKN IIIRSVCSEP CEKGQIKVIR KGEVSCCWTC
TPCKENEYVS DEYTCNACQL GSWPNDELTG CILIPVQYLR WGDPEPIAAV VFACLGLLAT
LFVTAIFIMY RDTPVVKSSS RELCYIILAG ICLGYLCTFC LIAKPQQIYC YLQRIGIGLS
PAMSYSALVT KTNRIARILA GSKKKICTKK PRFMSACAQL VIAFILICIQ LSIIVALFIM
EPPDIMHDYP SIREVYLICN TTNLGVVTPL GYNGLLILSC TFYAFKTRNV PANFNEAKYI
AFTMYTTCII WLAFVPIYFG SNYKIITMCF SVSLSATVAL GCMFVPKVYI ILAKPERNVR
SAFTTSTVVR MHVGDGKSSS AASRSSSLVN LWKRRGSSGE TLSSNGKSVS WAQNEKSSRG
AHLWQRLSIH INKKENPNQT AVIKPFSKST DSSRHSSSTT IPETSAKMLY DVSEAEEHYP
AQYRPQTPSP VSTVSHRTAS VSRTDDDVPT FQTENTQRSS SSQGSLMEQI SSVVTRFTAN
ISELNSMMLS TTTPGAMVAT PLCSSYLIPR EIQLPTTMTT FAEIQPLPAI EVNGASQSAR
KPSNGSIKEG TSEAPPPAKQ DLEELVALTP PSPFRDSIDS GSASPSSPVS ESALCIPSSP
KYDTLIIRDY TQSSSSL
//
