ID   A0A1U7S8B7_ALLSI        Unreviewed;       616 AA.
AC   A0A1U7S8B7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 2.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN   Name=ADCY9 {ECO:0000313|RefSeq:XP_006036635.2};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006036635.2};
RN   [1] {ECO:0000313|RefSeq:XP_006036635.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   RefSeq; XP_006036635.2; XM_006036573.3.
DR   AlphaFoldDB; A0A1U7S8B7; -.
DR   KEGG; asn:102373860; -.
DR   eggNOG; KOG3618; Eukaryota.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR   PANTHER; PTHR45627:SF8; ADENYLATE CYCLASE TYPE 9; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   DOMAIN          399..526
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   616 AA;  69800 MW;  4AF097A09D151932 CRC64;
     MASPPHQQLL HHHSTEVSCD PSGDSNSVTV RINPKQHQGC ISAKHCKYSI SSSCSSSGES
     AGPRRAAGGG ASGGSGLRRQ KKVPQLFERA SSKWWNPKFD SNNLEEACME RCFPQTQRRF
     RYALFYIGVA CLVWGIYFSI HMQEKLMVFT VPALGFLLVC IAFFMFTFTQ TYARHYVWTS
     LILTLLVFTL TLAPQFQALT TLSGRDDVSN HTSLVRAADA SLSQVGSFSM CIEVLLLLYT
     VMHLPLYLSL FLGLLYSVLF ETFGYHFRVE YNFTPIEANA AYWEQLMSKT LLHICIHAIG
     IHLFIMSEVR SRSTFLKVGQ SIMHGKDLEV EKALKERMIH SVMPRIIADD LMKQGDDESE
     NSVKRHSTSS PKSRKKKPSI QKTPIIFRPF KMQQIEQVSI LFADIVGFTK MSANKSAHAL
     VGLLNDLFGR FDRLCEDTKC EKISTLGDCY YCVAGCPEPR ADHAYCCIEM GLGMIKAIEQ
     FCQEKKEMVN MRVGVHTGTV LCGILGMRRF KFDVWSNDVN LANLMEQLGV AGKVHISEAT
     AKYLDDRYEM EDGKVIERVG QSVVADQLKE TLPLRPELII KDGWQDYKKC LRRFRETAGK
     RKGDIQQRNW WGQNRS
//