ID A0A1U7S8B9_ALLSI Unreviewed; 495 AA.
AC A0A1U7S8B9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=MARVEL domain-containing protein 2 {ECO:0000313|RefSeq:XP_006033073.3};
GN Name=MARVELD2 {ECO:0000313|RefSeq:XP_006033073.3};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006033073.3};
RN [1] {ECO:0000313|RefSeq:XP_006033073.3}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR RefSeq; XP_006033073.3; XM_006033011.3.
DR AlphaFoldDB; A0A1U7S8B9; -.
DR STRING; 38654.A0A1U7S8B9; -.
DR KEGG; asn:102388043; -.
DR eggNOG; KOG4796; Eukaryota.
DR InParanoid; A0A1U7S8B9; -.
DR OrthoDB; 2910197at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288:SF3; MARVEL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF01284; MARVEL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..312
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 379..490
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_006033073.3"
SQ SEQUENCE 495 AA; 56666 MW; D86718A5DC40E9FF CRC64;
RHVAPPPLPR LPPFGPDFYP SDSEEEAPAP PPHIKPVRRF VPDSWKKFFS GRRHVPKWGQ
GQDQPQPVGT RCSPPPSLPP GPESGASSYP DPSGMSGGSC PWRLETEAIL PPEPSGAARA
YSEEVEAYHR RYDYMKSWAG LLRILGVVQL LLGAAVFACI TAYVHKDNEW YNMFGYSQPY
SFGASSMYGG YYYSGPKTPF VLVVAGLVWI VTVVLLVLGM SMYYRTILLD SSWWPLTEFG
INIALFILYM AAAIVYVNDA NRGGLCYYPL FNTPLNASFC RIEGGQTAAM IFLFVTMIVY
LISAIVCLKL WRHEGARRHR ELMEQEMKTQ TVPPKRMYEN DDRPQEEVGY RQLKSVEVKP
ELLNGHIPAG HIPKPIVMPD YLAKYPAIQT DEMRERYKAV FNDQFAEYKE LSAEVQAVLK
KFDELDTWMR KLPHHSGNML EQERISKVLQ EYNTKKNDPS FLEKKERCEY LKNKLSHIKQ
RIQDYDKVMN WNVQT
//
