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Database: UniProt
Entry: A0A1U7S8F5_ALLSI
LinkDB: A0A1U7S8F5_ALLSI
Original site: A0A1U7S8F5_ALLSI 
ID   A0A1U7S8F5_ALLSI        Unreviewed;       163 AA.
AC   A0A1U7S8F5;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE            Short=FGF {ECO:0000256|RuleBase:RU049442};
GN   Name=FGF5 {ECO:0000313|RefSeq:XP_006027390.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006027390.1};
RN   [1] {ECO:0000313|RefSeq:XP_006027390.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation and cell differentiation. Required for normal regulation
CC       of the hair growth cycle. Functions as an inhibitor of hair elongation
CC       by promoting progression from anagen, the growth phase of the hair
CC       follicle, into catagen the apoptosis-induced regression phase.
CC       {ECO:0000256|ARBA:ARBA00025188}.
CC   -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC       growth factors (FGFs) and their receptors is increased by heparan
CC       sulfate glycosaminoglycans that function as coreceptors.
CC       {ECO:0000256|ARBA:ARBA00026062}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR   RefSeq; XP_006027390.1; XM_006027328.1.
DR   AlphaFoldDB; A0A1U7S8F5; -.
DR   STRING; 38654.A0A1U7S8F5; -.
DR   GeneID; 102371490; -.
DR   KEGG; asn:102371490; -.
DR   CTD; 2250; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   InParanoid; A0A1U7S8F5; -.
DR   OrthoDB; 2883843at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00058; FGF; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR   PANTHER; PTHR11486:SF23; FIBROBLAST GROWTH FACTOR 5; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          127..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   163 AA;  18537 MW;  A11977359CF245A2 CRC64;
     MVIYFGISVI LGILEIFAVS QGIVGIRGVF SNNFLAMSKK GKLHASAKFT EDCKFRERFQ
     ENSYNTYASA IYRTEKTGRE WYVALNKRGK AKRGCSPRVK PQHISTHFLP RFKQSEQPEL
     SFTITVPEKK KSPASTPAKP KVSLSVPQKN PNTVKYRLKF RFG
//
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