ID A0A1U7S8Q5_ALLSI Unreviewed; 2437 AA.
AC A0A1U7S8Q5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Tenascin isoform X1 {ECO:0000313|RefSeq:XP_006031179.1};
GN Name=TNC {ECO:0000313|RefSeq:XP_006031179.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006031179.1};
RN [1] {ECO:0000313|RefSeq:XP_006031179.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_006031179.1; XM_006031117.3.
DR STRING; 38654.A0A1U7S8Q5; -.
DR GeneID; 102379949; -.
DR KEGG; asn:102379949; -.
DR CTD; 3371; -.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2579; Eukaryota.
DR eggNOG; KOG3544; Eukaryota.
DR InParanoid; A0A1U7S8Q5; -.
DR OrthoDB; 5489847at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00063; FN3; 14.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR Pfam; PF07974; EGF_2; 6.
DR Pfam; PF18720; EGF_Tenascin; 8.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 16.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 12.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 14.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2437
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010522236"
FT DOMAIN 188..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 436..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 560..591
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 622..653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..778
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 868..958
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 959..1049
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1050..1138
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1170..1265
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1311..1401
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1402..1492
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1493..1583
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1584..1674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1675..1767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1858..1947
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1948..2037
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2038..2124
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2125..2213
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2211..2426
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 1042..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 192..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 440..450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 457..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 564..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 581..590
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 626..636
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 643..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2437 AA; 267049 MW; CD193AF06DA439FE CRC64;
MGLPTQVLAC AIIVLLHQHV SGGLIKRIIR QKREAGLNVT LPDDNQPVVF NHVYNIKLPV
GSLCSVDLDS ASGDADLKAE IEPSKHYEEH TVNEDNQIVF THRINIPRRA CGCASAPDIK
DLLNRLEELE GLVSSLREQC TIGAGCCPSA QTAEGRVDTT PFCSGRGNYS TEICGCICDP
GWKGPNCSEP ECLNNCYNRG RCVNGKCICD EGFTGKDCSE LTCPGDCNDQ GKCIDGVCVC
FEGYTGEDCV EELCLPPCSE HGKCVNGRCV CVEGFTGEDC GEPLCLNNCN NRGRCVENEC
VCDEGYTGED CGELICPNDC FDRGRCINGT CYCEEGYTGE DCGELTCPNN CNGNGRCENG
QCLCDEGFVG DDCSERRCPK DCNKRGRCID GQCVCNEGFE GIDCGQVKCP KDCNNRGQCV
NGQCVCNEGF MGEDCGVLRC PKDCSNHGRC INGQCECDEG FMGEDCSELK CPNDCHNRGR
CVKGHCVCDE GFIGEDCGEL RCPNDCYNRG RCVKGICVCD EGFVGNDCSE LRCPNDCSKH
GRCVNGQCVC DEGYTGEDCS ELRCPNDCHN RGRCVDGECL CEKGFTGVDC GELACLDNCN
NRGRCENGQC VCNEGFTGID CSQLRCANDC NNQGRCIEGQ CVCDEGFTGE DCSQRSCLNN
CNNLGRCVDG RCICDNGYIG DDCSDVSPPS DLTVTNVTDK TVNLEWKNEN LVNQYLITYV
PTSIGGLDMQ FTVPGNQTSA TIRELEPGVE YFIRVFAILK NKKSIPISAR VATYLPAPEG
LKFKSVRETS VQVEWDPLNI SFDGWELIFR NMKKEDNGDI TRSLTRPETS YMQPGLAPGQ
QYNVSLHIVK NNTRGPGLSK VITTKLDAPS QIEAKDVTDT TALITWFKPL AEIDGIELTY
GPKDVPGDKT TIDLSEDENQ YSIGDLKPFT EYEVVLISRR GDMESDPMSE VFLTDLDAPK
NLKRVSQTDN SITLEWKKSQ ADIDSYRVKF APISGGDHAE ITVPKSNQAT TKATLTGLRP
GTEYGIGVTA VKEDTESAPA TINAGTDLDS PKDLGVNNPT ETSLSLSWRR PLAKFDRYRL
TYVTPSGRKN EVEIPADSTS YILQGLDAGT EYTTSLIAEK GRHKSKPTTV KSSTAVYSLE
LMQGATPGPD EHSGFWSSPA PEASGMWEAT LWDLLVSNVT DHGFGLSWKA DAGAYTSFVV
EYEEVTLAAG PPAEVFMPGE SLGAVIDGLQ ANATYKVKVY GMAGGQRSHP LEAVATTALL
VTAPGESNNE TSFNSTYPAP TELSYLTIPS TDSHTVLSAP TAFFISDVTA QLHDLKVTGR
TFSSFTLTWA AQDEVFDQFF ITLKDLSSLN RTLEIFLPGS QRETEFTNLT AGTQYQINLH
GSARGQLSQS LEAITNTAEE PELGNLTVSE VSWDGFQPTW TAADGAFETF VLQVQESDNP
EEVQNHTVPG GLRFVNITAL KDYTRYNITL YGVIQGYRTK PLSAETTTAM RAEVGELNVS
GITPEGFNLS WTATERAFEI FTIEIINSNR FLEPMEYNIS GNLRTAHISG LSPSTDYIVY
LYGITPGFRT QAISVAVTTV DEPLLSKLTV SNATSNSVSL TWEAQDTAFD HFVLEVRNSD
LPLDSLVHTV SGASRSFVIT NLRAATNYTV QLHGLVDGQS GQTLTAVATT EAEPQLGTLT
LTNVTPDSFN LSWTTRNGPF AKFVINVRDS YSAHEPQELT VSGGARSAHI SGLVDYTGYD
INIKGTTSAG VHTEPLTAFV MTEAMPPLEN LTVSDINPYG FTVSWMASEN AFDNFLVIVV
DSGKLLDPQE FLLTGTQRHL KLKGLITGIG YEVMLYGFAK GRQTKPLSIV AITEAEPEVD
NILVSDITPD GFRLSWTADD GVFDSFFIKI RDTKKQSDPW ERIVPGHERT QDITGLKEGT
EYEIELYGII SGRRSQPINA IAITAMGSPK GINFTDITEN SATVTWMLPR TRVESFRILY
APKTGGTPNI VTVDGTKTRT KLVKLVPGVE YVVNITSVKG FEESEPVSGP LKTALDSPSG
LVVVNITDSE ALATWQPAIA AVDNYVISYI SETEPEVKQM VSGNTVEYDL NGLRPATEYV
LRLHAVEDGQ QSATISTKFT TGMDAPRDLR AIDIQSETAV LTWRPPRASL TGYLLIYESA
DGKVKEVILV PETTSYDLTE LSPSTQYTVK LRALHRSLKS NIIQTVFTTS GLLYPFPKDC
SQALLNGETA SGLYTIYLNG EKSQPLEVYC DMGSDGGGWI VFLRRRNGKE DFYRNWRTYS
AGFGDPKDEF WIGLENLHKI TSQGQYELRV DLRDKGETAF AIYDKFSVGD SKTRYRLKVD
GYTGTAGDSM TYHNGRSFST YDKDNDFAIT NCALSYKGAF WYKNCHRVNL MGRYGDNSHS
QGINWFHWKG HEYSIEFAEM KLRPSSFRNL EGRRKRA
//
