ID A0A1U7SBV2_ALLSI Unreviewed; 1099 AA.
AC A0A1U7SBV2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Solute carrier family 12 member 1 isoform X2 {ECO:0000313|RefSeq:XP_006029101.1};
GN Name=SLC12A1 {ECO:0000313|RefSeq:XP_006029101.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006029101.1};
RN [1] {ECO:0000313|RefSeq:XP_006029101.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006029101.1; XM_006029039.2.
DR AlphaFoldDB; A0A1U7SBV2; -.
DR GeneID; 102384360; -.
DR KEGG; asn:102384360; -.
DR CTD; 6557; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002445; Slc12a1.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01209; NAKCLTRSPRT2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 256..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..156
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 182..685
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 694..1099
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 27..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 824..851
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 121698 MW; 2ED3BDD2B586AED5 CRC64;
MSMNNSPSVF LDPNANRFQV NVINESHGHD NSATSQEDTD PPHYEETSFA DEAHNRLRIS
FRPGTRQLYD NFLQNGDTAK PDANIHPYDT HSNTYYLQTF GHNTMDPIPK IDYYRNTGSI
SGVKISRPSL LEIHEQLAKN IAVNPGSIDR VANGEGTPGD DVTANKEEEN KGGFVKFGWV
KGVLVRCMLN IWGVMLFIRL SWIIGQAGIG LGVIIILLAT MVTSITGLST SAIATNGFVR
GGGAYYLISR SLGPEFGGSI GLIFAFANAV AVAMYVVGFA ETVVELLKSS NAMMVDESND
IRIIGSITIV ILLGISVAGM EWEAKAQVIL LIILLVAIIN FFIGTVIPTS NEKRARGFFN
YQASIFAENF GPGFRDGEGF FSVFAIFFPA ATGILAGANI SGDLEDPQSA IPKGTMLAIL
ITTIAYLGVA ICAAACVVRD ATGNVNDTVV SGTNCNGSSA CALGYDFSSC KSQPCAYGLM
NDFQVMSMVS GFGPLITAGI FSATLSSALA SLVSAPKVFQ ALCKDNIYKA LHFFAKGYGK
NNEPIRGYIL TFVIAMAFIL IAELNTIAPI ISNFFLASYA LINFSCFHAS YAKSPGWRPA
FRYYNMWVSL FGAALCCGVM FVINWWAALI TYAIELFLYI YVTYKKPEVN WGSSAQALYY
VNALESALAL TTVEDHVKNF RPQCIVLTGA PMTRPALLDI THSFTKSNGL CICCEVYTGP
RKLCVQEMNS GMAKKQAWLT KNKRKAFYAA VAADSFRDGV KSLLQASGLG RMKPNTLVLG
FKKDWRNASA MQVENYVGVI HDAFDFELGL IIVRTSQGFD ISQVLQVQEE LEKLEQERLA
LETTIKDNDF EEGRYGIRGF FNKASKLSIA KHETRKDSNI NTIQSIHMDE FNQRLLEANS
QFKKKHGKGT IDVWWLFDDG GLTILIPYIL TTQKKWKDCK LRIFTGGKVN RIEDEKLGMA
SLLSKFRIKF ADINIICDIN MKPNKESWKF FEEMIEPYRL HESCKDLTTA EKLKREAPWK
ITDAELEAFK EKSYRQVRLN ELLQEHSRGA NLIVLSLPVA RKGVVSDHLY MAWLEILSKN
LPPILLVRGN HKNVLTFYS
//