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Database: UniProt
Entry: A0A1U7SBV2_ALLSI
LinkDB: A0A1U7SBV2_ALLSI
Original site: A0A1U7SBV2_ALLSI 
ID   A0A1U7SBV2_ALLSI        Unreviewed;      1099 AA.
AC   A0A1U7SBV2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Solute carrier family 12 member 1 isoform X2 {ECO:0000313|RefSeq:XP_006029101.1};
GN   Name=SLC12A1 {ECO:0000313|RefSeq:XP_006029101.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006029101.1};
RN   [1] {ECO:0000313|RefSeq:XP_006029101.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC         K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC         ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   RefSeq; XP_006029101.1; XM_006029039.2.
DR   AlphaFoldDB; A0A1U7SBV2; -.
DR   GeneID; 102384360; -.
DR   KEGG; asn:102384360; -.
DR   CTD; 6557; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR013612; AA_permease_N.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002445; Slc12a1.
DR   InterPro; IPR002443; SLC12A1/SLC12A2.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF08403; AA_permease_N; 1.
DR   Pfam; PF03522; SLC12; 1.
DR   PRINTS; PR01207; NAKCLTRNSPRT.
DR   PRINTS; PR01209; NAKCLTRSPRT2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        256..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        380..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        545..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        603..627
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          89..156
FT                   /note="Amino acid permease N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08403"
FT   DOMAIN          182..685
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          694..1099
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          27..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          824..851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        31..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1099 AA;  121698 MW;  2ED3BDD2B586AED5 CRC64;
     MSMNNSPSVF LDPNANRFQV NVINESHGHD NSATSQEDTD PPHYEETSFA DEAHNRLRIS
     FRPGTRQLYD NFLQNGDTAK PDANIHPYDT HSNTYYLQTF GHNTMDPIPK IDYYRNTGSI
     SGVKISRPSL LEIHEQLAKN IAVNPGSIDR VANGEGTPGD DVTANKEEEN KGGFVKFGWV
     KGVLVRCMLN IWGVMLFIRL SWIIGQAGIG LGVIIILLAT MVTSITGLST SAIATNGFVR
     GGGAYYLISR SLGPEFGGSI GLIFAFANAV AVAMYVVGFA ETVVELLKSS NAMMVDESND
     IRIIGSITIV ILLGISVAGM EWEAKAQVIL LIILLVAIIN FFIGTVIPTS NEKRARGFFN
     YQASIFAENF GPGFRDGEGF FSVFAIFFPA ATGILAGANI SGDLEDPQSA IPKGTMLAIL
     ITTIAYLGVA ICAAACVVRD ATGNVNDTVV SGTNCNGSSA CALGYDFSSC KSQPCAYGLM
     NDFQVMSMVS GFGPLITAGI FSATLSSALA SLVSAPKVFQ ALCKDNIYKA LHFFAKGYGK
     NNEPIRGYIL TFVIAMAFIL IAELNTIAPI ISNFFLASYA LINFSCFHAS YAKSPGWRPA
     FRYYNMWVSL FGAALCCGVM FVINWWAALI TYAIELFLYI YVTYKKPEVN WGSSAQALYY
     VNALESALAL TTVEDHVKNF RPQCIVLTGA PMTRPALLDI THSFTKSNGL CICCEVYTGP
     RKLCVQEMNS GMAKKQAWLT KNKRKAFYAA VAADSFRDGV KSLLQASGLG RMKPNTLVLG
     FKKDWRNASA MQVENYVGVI HDAFDFELGL IIVRTSQGFD ISQVLQVQEE LEKLEQERLA
     LETTIKDNDF EEGRYGIRGF FNKASKLSIA KHETRKDSNI NTIQSIHMDE FNQRLLEANS
     QFKKKHGKGT IDVWWLFDDG GLTILIPYIL TTQKKWKDCK LRIFTGGKVN RIEDEKLGMA
     SLLSKFRIKF ADINIICDIN MKPNKESWKF FEEMIEPYRL HESCKDLTTA EKLKREAPWK
     ITDAELEAFK EKSYRQVRLN ELLQEHSRGA NLIVLSLPVA RKGVVSDHLY MAWLEILSKN
     LPPILLVRGN HKNVLTFYS
//
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