ID   A0A1U7SF73_ALLSI        Unreviewed;       804 AA.
AC   A0A1U7SF73;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Leucine-rich repeat and guanylate kinase domain-containing protein isoform X1 {ECO:0000313|RefSeq:XP_006030744.3};
GN   Name=LRGUK {ECO:0000313|RefSeq:XP_006030744.3};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006030744.3};
RN   [1] {ECO:0000313|RefSeq:XP_006030744.3}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006030744.3; XM_006030682.3.
DR   AlphaFoldDB; A0A1U7SF73; -.
DR   STRING; 38654.A0A1U7SF73; -.
DR   KEGG; asn:102372831; -.
DR   eggNOG; KOG0531; Eukaryota.
DR   eggNOG; KOG0707; Eukaryota.
DR   InParanoid; A0A1U7SF73; -.
DR   OrthoDB; 1331402at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00071; GMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR   PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   4: Predicted;
KW   Kinase {ECO:0000313|RefSeq:XP_006030744.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transferase {ECO:0000313|RefSeq:XP_006030744.3}.
FT   DOMAIN          350..533
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          554..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..32
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  90011 MW;  49C029F945F6683D CRC64;
     MAAPMGEVAS ALPLPQQQDE EEDEEESDLE PPPMEEHFDG VLNDDIIAEA LYKLGRSALG
     TEYVYLNLSL SGRNLSDINI LSKYVHLEKL ELSYNKINDL SCVSHMPYLL ELDASNNELT
     TYFNFKPPKS LKEVDFSYNQ ISAMRDLSAY QSLTRLILDH NNIEEIKGLE KCRSLIHLSL
     AHNRITTING LKNLPIKTLC LRANQIEKIT GLEELRALQH LDLSSNNISS LGGLEEHYLL
     EVINLEDNQI ADLGELEYIE DLPLLRGLNL LNNPVQERTE YWLLVIFMLL RLTELDNKKI
     TVEEKVAAVN KYDPPPEVVG AKDHITHVMY SLMQPQRIFD STLPSLDAPY PMLIFVGPVA
     CGKRELTHRI CRQFNNFFRY SPCHTTRAPY FGEENRLDFY FVSQEAFDKM VNMGKFIATY
     KYSGYYYGLG RETVESIARE GLASCVHLEI EAVRSLKNSY FQPRYILLVP MNKERYEGHL
     RRKGIFSRPE IEEAITRVDM YIKINQDSPG YFDAIIDTDD LDEAYTKLSL IIKEYLGLEQ
     PSFSDGNLYL DSKPIRGART PSTGDHRTPT GGETTRLAHP SAPGEFLSSS ARNYAVRISA
     HLSTQKTPVE EASLQRRREA AHRALNGKAP GAYAQLFQSN HASTTAAASP RQQLLEPPTR
     SSLFPSGSNL TQDRSLPPAS PDTSNRDGRT SKIKNLTGSK ESCTTTGLSI TSSAHAFSME
     SLSVPSPAPN TRYPEDTNTE HTDIGGIGNG TANTKDIEPS SDSLEKKASR SKSSSRVPQV
     TNRPGSDTKP VLPPIPSGRK RTKP
//