ID A0A1U7SHB3_ALLSI Unreviewed; 171 AA.
AC A0A1U7SHB3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6 {ECO:0000256|ARBA:ARBA00019579, ECO:0000256|PIRNR:PIRNR037609};
DE Short=BLOC-1 subunit 6 {ECO:0000256|PIRNR:PIRNR037609};
GN Name=BLOC1S6 {ECO:0000313|RefSeq:XP_006030487.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006030487.1};
RN [1] {ECO:0000313|RefSeq:XP_006030487.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC May play a role in intracellular vesicle trafficking, particularly in
CC the vesicle-docking and fusion process.
CC {ECO:0000256|PIRNR:PIRNR037609}.
CC -!- SIMILARITY: Belongs to the BLOC1S6 family.
CC {ECO:0000256|ARBA:ARBA00005767, ECO:0000256|PIRNR:PIRNR037609}.
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DR RefSeq; XP_006030487.1; XM_006030425.3.
DR AlphaFoldDB; A0A1U7SHB3; -.
DR STRING; 38654.A0A1U7SHB3; -.
DR GeneID; 102372905; -.
DR KEGG; asn:102372905; -.
DR CTD; 26258; -.
DR eggNOG; ENOG502RZNC; Eukaryota.
DR InParanoid; A0A1U7SHB3; -.
DR OrthoDB; 2970759at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR017242; BLOC-1_pallidin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR PANTHER; PTHR31328; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR PANTHER; PTHR31328:SF2; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037609; BLOC-1_complex_pallidin; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 171 AA; 19424 MW; 86B4E1F21635496C CRC64;
MSGAEPAAGE AGASLEPPGP RPLAPGSNDA SPDEGLVEDL CLVDERAVEQ LTEGLISHYL
PDLQQSKQAL QELTQNQAVL LDTLEQEISK FKECNSILDI NTLFLEAKHY HSKLVNIRKE
MLMLHEKTSK LKKRALKLQQ KRQKEELERE QQREREFERE KQLTAKPAKR T
//