ID A0A1U7SM25_ALLSI Unreviewed; 3391 AA.
AC A0A1U7SM25;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein {ECO:0000313|RefSeq:XP_006038244.1};
GN Name=ASPM {ECO:0000313|RefSeq:XP_006038244.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006038244.1};
RN [1] {ECO:0000313|RefSeq:XP_006038244.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006038244.1; XM_006038182.3.
DR STRING; 38654.A0A1U7SM25; -.
DR GeneID; 102387151; -.
DR KEGG; asn:102387151; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; A0A1U7SM25; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 30.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 39.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 65.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 16.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 38.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 807..943
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 994..1145
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 943..970
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3391 AA; 397207 MW; 5059CA1769274FCB CRC64;
MAAGGAAAWE LSPARRRRWG EAEDEEEPPA SGERIFISVT WTPLEEGRVR ELITFVVNGI
VKHQAILLGV AEQPERKKKS LGDGIRRKNP SEASITMRTR KTQSNIRKVN KTFRVSQKAD
KVRSPLQSCE NLEMREDNVS SRNKSLLTLE SNLPISPISP MLQEGNDFTC TPLSMRRSTT
YSVLHTAVNG EIISETDACT IKKSHNEETK SASSHNSSIE SLKAQRSDNE EVLNGMLSSV
CTPERSAALP ILTDKRFLSP DSFINDSYQV NVDVVPEQVV PILSPEQFVR DSFSAIQSVS
QLHESVLPSS SSSGEVCQTK RPTWEENQEK KVIALHVAKD FSNDDVLDDA YTVKSQLVNY
NKPKQNHLSF PNPVCSHSQR EKLKKRPVLS ATVIKNKPEV PEGKVIQTGN SKSRKCLNSA
ITECASVVPG HTGAEIYQYL PVIEPISGEI EDYKVEASSL STGSTSLCRK RKSEVFFGDH
KAMAPECTEE TETKRIFISC MDNKEQTTQR LPVSKSFTNR EKLTWRKKVG SSLQKASKTS
NRTTKPVVGV AQSHLTFVKP LKTVIPRHPM PFVAKNMFYD ERWKEKQQRG FTWWLNFILT
PDDFTVKTNI SQVNAAVLVL GAEHYKASVP KAPTKDEMSL RAYTARCRLN RLRRAACRLF
TCETMVKAIK KLEVEIETRR LLVRKDRHLW KDIGERQKIL NWLLSYNPLW LRIGLETVYG
ELIALESNSD VMGLAMFILN RLLWNPDIAA EYRHPSVPHL YRDGHEAALS KFTLKKLLLL
VCFLDCAKQS RIIDHNPCLF CKDAEFKTSK DILLAFARDF LSGEGDLSRH LGFLGLPVSH
VQTPLDEFDF AVTNLAVDLQ CGIRLVRAME LLSKNWTLSE KLRVPAISRL QKMHNVDIAL
NVLKERGVRL QDETGASISS RDIVDRHRER TLALLWKIVF AFQVEVSLNV EQLKEEIEFL
KNAHSIKTKM AALNLSVHKG RKNSSGYPTS ESYQENVKLL MDWVNAVCGF YNTKVENFSV
SFSDGRVLCY LIHHYHPYYM PLEAVCQRTT QTVECTKNGT VVLNSSSESD TSLNVLDGTF
GQTITTSVLY KELLDNEKNN FQLINAAVSD LGGIPAMIHH SDMSNTIPDE KVVITYLSFL
CSRLLDLRKE TRAARLIQSA WRKHRMKVEL KLFQEKDKAA QIIRRAVINF LSRRHVQKEV
TAAVFIQKHW RRFLAEKRIL QLKHARLEKI KSESAAVIQT YWRSYSARKR YLQLRYYVIL
VQARIRMLIA ATAYKRLLHA TITIQRRLRA FLLAKKVQQK YETLKCSTLI IQSAFRRWRK
LKIQQKAKAT LVLQIYFRKW QASKLAKRGR AAIVIQSWYR RNVARKQYLH VRKSIIKIQA
WFRCHHAKYL YEERRAKIQT IQKYYRACRL GTIERGKYLQ RRAAIIVLQA AFRGMKARLL
YRQIKAACVI QSLWRMRRER LRFLHVKQCV VLLQSHVRKY QQLKRYKRIK NAVSVIQIHC
RSYVASKRAC SHFWKMHLAV LVLQSAYRGM QARREARMLR SVVKIQSSYR AYVAQKKFKC
LKDSAVKIQA FVRMMQARKR YCSVKEATLY VQRRYRSQKH VLQFQEEYRK VKRACVQIQA
AARGYLVRKQ VQRWKEAATM LQAYYRMKRD KQRYLRLHTA TVIIQNHYRA YQEKVCQRQK
FLKIKEAAVC LQASYRGYRA RKMHKLQCTA AVKIQTAFRA HAARMKYHAM VQASVIIQRW
YKAYKTGSKE RSNFLKTRTA ALSLQAAFRG WKVRKNFRRQ HAAAVKIQSA FRKFRVQKRF
RLITNAVLTM QQHYRARTVG RKQHQEYVEL CNCVAHLQAI WRGRTVREHI QKQHQCAVII
QSYYRMHVTR SKLKTWREAA LMIQRHYRSH CMKKEQRMLY LKTKATVLVL QAAYRGMRAR
KQLKKLNKAA TIVQATYRSY MVRKKYEALR SATIVVQRWY CTVLETKYQR QEYLTLKKAV
IKMQAVYRGV KVRRQIHQMH QAAISIQAMF KMHRINIRYR AMKLAAVLIK KRYRAYCQGR
TERGKYLELC KSTLILQAAY RGMKVRQELR IMHQCATVIQ SYYRMYRQQR DFLKLSLVTR
QIQQLYRARK ERDARAHTYK VIKKSVLCIQ TAFRGMKTRR HLRTMHISAV LIQGRVRSFQ
QRKRYISLRA AAVMVQRKYR ATVIAKQQHQ EFLRLHKAAI TIQSAYRGFV VRKSIQQMHR
AATVIQAVIR MHKTYISYHA VRHASRIIQQ HYRAYREGKW VREIYLKQCN SVIVLQAAYR
GMRTRMLLKK KHNAATIIQR NYQMYKQHSY YKRVKWATKV TQQRYRANKL REAAVQRYSS
MKKAATCIQK TFRNMRAIRE YKKMHQAAVV IQRGFKMHRE RQKYLSLKAA TVVLQKRYRA
LLLARRQTGE YLCLRRAVIC MQSLYRGFQV RKNIQYMHLA AKTIQSAFRM YRVRIAYQNM
RISAVIIQNY YRAYVEGKIQ RKKYLTMQKS AVVIQAAYRG VKDRQKLKIM HASATVIQSF
YRMHRQHNYY KHICWAVGVI QQRFRAKKAR EAEVKNYTKI KQASLCLQSA FRARKATLLA
KNVLAAQHIQ SVLQMYTERK RFLKKRVAVV VIQSAFRCHQ TRTWFKAIQG STVVIQRWYR
ACRMARLLKA EYCVQRQAII TIQSAYRGMV ARKLAMRIRA ARKIQSFLHM AVHRRKFVKL
RAAAVMLQTY YLMQKVKLQY AMYRKAALIL QNHYRSHLAM KHQREAYLLT QKSIIVIQTR
IRGFNEWRRF QKIKQSTVKI QAFYRGFSQR RQYLQYKSSV VLIQQHYRAH CLRNMERQKY
LQIKAAALRL QALYRGFEAR QLAAKMRSAR MIQACFRGYR ARKELAAVVK AAGVIQRYHK
TRQQRIWFLK MKVSTVVIQR RWRAILSARA TLQQFLTVKE AAVKIQLAYQ RYSARKLIAK
KQQAACLIQA AYRGFKERQK FLQQKVAALV IQKHVRARWD GRLECIKYHR TRATIVKLQA
YIRGWLVRKK ILEEKQKKRL LYFTGATYHH LSAIKIQRSY RSYLVLKHAQ MQISSVICIQ
RWFRAKLQQK QFLQDRQKIV TIQRKARAWL NRRNEAATII QRAVRRFLCY QHRRKLNSGI
MKFQALWKGH SWRKSHDTAK TKALRHSLEI ANKNSREENK LCNRTAIAIE YLLQYKHISY
ILAALKHLEV VTRLSPRCCE DMAQSGAIFT IFTLIRSCNR SVPCMDVIKY SIQVLLNVSK
YEKTTQAVYE VESSIDTLLD LLQRYRGKAG DKISEKGGSI FTKTCCLLAI LLKNSRRASE
IQSKPRAVVR IQSLYKVIAR KHKMEAERTL SKHKTAAPVH GNYFVPVTPV RTKVVSRIKP
DWVLRKDNMR EIVDPLQAIR MVMDTLGVPY N
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