ID A0A1U7SR17_ALLSI Unreviewed; 258 AA.
AC A0A1U7SR17;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Synapse differentiation-inducing gene protein 1 {ECO:0000256|ARBA:ARBA00040240};
DE AltName: Full=Dispanin subfamily C member 2 {ECO:0000256|ARBA:ARBA00041354};
DE AltName: Full=Transmembrane protein 90B {ECO:0000256|ARBA:ARBA00042246};
GN Name=SYNDIG1 {ECO:0000313|RefSeq:XP_006035035.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006035035.1};
RN [1] {ECO:0000313|RefSeq:XP_006035035.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC have a role in postsynaptic development and maturation.
CC {ECO:0000256|ARBA:ARBA00037790}.
CC -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2.
CC {ECO:0000256|ARBA:ARBA00038680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell
CC projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR RefSeq; XP_006035035.1; XM_006034973.3.
DR AlphaFoldDB; A0A1U7SR17; -.
DR STRING; 38654.A0A1U7SR17; -.
DR GeneID; 102372003; -.
DR KEGG; asn:102372003; -.
DR CTD; 79953; -.
DR eggNOG; ENOG502QQXK; Eukaryota.
DR InParanoid; A0A1U7SR17; -.
DR OrthoDB; 4253341at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14768:SF3; SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1; 1.
DR PANTHER; PTHR14768; UPF0338 PROTEIN; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 182..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 258 AA; 28753 MW; 7CFD14C6AE8084F7 CRC64;
MDGLIEQNSV LMHSKISEAG KKNGLINTRN LVAENRDGLV SVYPTPQYQS RRAGNLPPQG
CLENGKNDSV QQLLDPNTLQ QTVESHYRPN IILYSENMLR AWGDSVSAEC CETTFIEDRS
PTKDSLEYPD SKFIDLSGDD IKIHTLSYDV EEEEDFQELE SDYSSDTESE DNFLMMPPRD
HLGLSVFSML CCFWPLGIAA FYLSHETNKA VAKGDFHQAS SSSRRALFLA VLSITIGTGI
YVGVAVALIA YLSKNNHL
//
