ID A0A1U7ST57_ALLSI Unreviewed; 297 AA.
AC A0A1U7ST57;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN Name=METTL6 {ECO:0000313|RefSeq:XP_006037520.1,
GN ECO:0000313|RefSeq:XP_025049657.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006037520.1};
RN [1] {ECO:0000313|RefSeq:XP_006037520.1, ECO:0000313|RefSeq:XP_025049657.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR RefSeq; XP_006037519.1; XM_006037457.2.
DR RefSeq; XP_006037520.1; XM_006037458.3.
DR RefSeq; XP_025049657.1; XM_025193872.1.
DR STRING; 38654.A0A1U7ST57; -.
DR GeneID; 102386142; -.
DR KEGG; asn:102386142; -.
DR CTD; 131965; -.
DR eggNOG; KOG2361; Eukaryota.
DR OrthoDB; 5471626at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037755};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037755};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 108..206
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
SQ SEQUENCE 297 AA; 34701 MW; 2D32081B68772A53 CRC64;
MDEFRMSQED VSANHPNVIV PTCEGNTFQK KAHSIRTLSA EEAEKLARDQ TLVSDFKQSK
LEKEAQKNWD LFYKRNSTNF FKDRHWTTRE FEELKACREF ENQKLTILEA GCGVGNCLFP
LLKEDFNIFA YACDFSPRAV EYVKKNPSYN IERCKVFQCD LTKDDLLENI PANSVDVVTL
IFVLSAIHPD KMHLVLQNIY KVLKPGKCIL FRDYGLYDHA MLRFKSGSKL GDNFYVRQDG
TRSYFFTHEF LSQLFMAEGY EQVVNEYVLR ETVNRKEGLC VPRIFLQSKF RKPLSKP
//
