ID A0A1U7SY19_ALLSI Unreviewed; 1002 AA.
AC A0A1U7SY19;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Integrin alpha-X {ECO:0000313|RefSeq:XP_006038789.1};
GN Name=LOC102378028 {ECO:0000313|RefSeq:XP_006038789.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006038789.1};
RN [1] {ECO:0000313|RefSeq:XP_006038789.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_006038789.1; XM_006038727.3.
DR AlphaFoldDB; A0A1U7SY19; -.
DR STRING; 38654.A0A1U7SY19; -.
DR GeneID; 102378028; -.
DR KEGG; asn:102378028; -.
DR eggNOG; KOG3637; Eukaryota.
DR InParanoid; A0A1U7SY19; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF118; INTEGRIN ALPHA-X; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 937..963
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 33..213
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 330..390
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 393..451
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 455..515
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REGION 978..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 109768 MW; C2AF79F8EBF8FE47 CRC64;
MYVRGYCFLL DRNLRLTQRF PETLPECPRR QTDILFLIDG SGSVVSSDFL KMKDFVVQVM
RRFRGTETQF AVMQFSSDFT TAFDFKEFRE SSEVHIEERV QRIVQKGYTT WTASAIRRAV
QEVFVSKSGM RAGATKVLIV ITDGMKFQDT LHYADVIPEA DRAGIIRYAI GVGNAFFDEN
AQRELRMIAS SPASDHIFQV DNFNALQGLQ EKLKNKIFAI EGTQSHSDSS FQLEMSQDGF
SALLYQDFCV LGAVGAYDWS GGLVLYKQSE NPTFINVSRT SKEMNDAYLG YAVQPVASRG
RRGYVVGAPR YQHVGKVVLF YWDPKESAWK AEGKVKGDQI GSYFGGSLST MDVDGDGNTD
LILIGAPMYY GEGSGGRVFM CPLPKQRAPL RCDGVLRGQG NQPLGRFGAS LAVLGDVDGD
GRADLAVGAP LEDGAHGALY IFRGQQRHLR NQPSQRISGT WGSRAPQALG LALSGGADLT
GDNLKDIAVG ANGQVLLLRS RPVLQATVTV TFAPTTIPTT AFNCQGREQL GAKAATAQVC
FSLRLNPKQH FKGSSISGTF RYELVLDPGR VKVRAAFDPP LSAQSQMVQV SLPPQCQNYN
VQLPVCPEDT LAPITLRLTY NLTGNPIPST NGLTPILAED TEPMVVASLP FDKNCGSDGV
CEDNLQIAFN FSGLSTLVVG DTQDLQVTIQ VHNLGEDSYG ATMRLLHPAV LSYRKVQVLQ
VVFATTLDVP TTAELGDRLQ LLAVTRSDNH GPGNESKSQS VELPVKYAIH IIITGGEDST
QYTNFSSKEE EATRTVIHRY EIRNLRQRSP PLWVTFEFPV AVNGVPMWVT APKLANCYTL
PETPGIKDVS EEMKKSPLLG CAVTTCQRVR CNVSAVYMEQ PLEFVLTGNI SFGWFSQTGR
DKVTLVSTAE VGADPGRFHQ QGTVRHQVQT VLERVHIYNY VPIIVGSSIG GLLLLALITA
ALYKFGFFRR QYKEMMESAK EGEGSAPTPG SALGPTPSAP QQ
//
