GenomeNet

Database: UniProt
Entry: A0A1U7T5F5_TARSY
LinkDB: A0A1U7T5F5_TARSY
Original site: A0A1U7T5F5_TARSY 
ID   A0A1U7T5F5_TARSY        Unreviewed;       473 AA.
AC   A0A1U7T5F5;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   18-SEP-2019, entry version 15.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL2 {ECO:0000313|RefSeq:XP_008051608.1,
GN   ECO:0000313|RefSeq:XP_008051609.1, ECO:0000313|RefSeq:XP_021565794.1};
OS   Tarsius syrichta (Philippine tarsier).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Tarsiiformes; Tarsiidae; Carlito.
OX   NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008051608.1};
RN   [1] {ECO:0000313|RefSeq:XP_008051608.1, ECO:0000313|RefSeq:XP_008051609.1, ECO:0000313|RefSeq:XP_021565794.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_008051608.1; XM_008053417.1.
DR   RefSeq; XP_008051609.1; XM_008053418.1.
DR   RefSeq; XP_021565794.1; XM_021710119.1.
DR   GeneID; 103255457; -.
DR   CTD; 8692; -.
DR   OrthoDB; 1096692at2759; -.
DR   Proteomes; UP000189704; Genome assembly.
DR   GO; GO:0031362; C:anchored component of external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0090575; C:RNA polymerase II transcription factor complex; IEA:Ensembl.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
DR   GO; GO:0033906; F:hyaluronoglucuronidase activity; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030294; F:receptor signaling protein tyrosine kinase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR   GO; GO:0001618; F:virus receptor activity; IEA:Ensembl.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR   GO; GO:0042117; P:monocyte activation; IEA:Ensembl.
DR   GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
DR   GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0010764; P:negative regulation of fibroblast migration; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
DR   GO; GO:2000484; P:positive regulation of interleukin-8 secretion; IEA:Ensembl.
DR   GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   GO; GO:0000302; P:response to reactive oxygen species; IEA:Ensembl.
DR   GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0019087; P:transformation of host cell by virus; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000189704};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    473       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010665016.
FT   ACT_SITE    135    135       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    357    357       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     47    340       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    211    227       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    365    376       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    370    427       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    429    438       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   473 AA;  53825 MW;  FE25F6BC2A3AEA61 CRC64;
     MWAGPGPTIT LALVLAVTWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF
     DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNGSLWAHL KMLRKGVEHY
     IRTQEPAGLA VIDWEDWRPV WVRNWQDKDV YRQSSRQLVA SRHPDWPSDR IVKQAQYEFE
     FAARQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNHQLAW
     LWAESTALFP SVYLDETLNS STHGRNFVSF RVREALRVAH THHANHALPV YVFTRPTYSR
     RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTQL LVPYVVNVSW
     ATQYCSWAQC HGHGRCVRRN PSSNTYLHLS ANSFRLVPGH SPGDPQLRPV GELSWADLDH
     LQTHFRCQCY LGWGGDQCQW DHRRAAGGAS RAWAASHLTS LLALAALAFI WTL
//
DBGET integrated database retrieval system