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Database: UniProt
Entry: A0A1U7TT34_TARSY
LinkDB: A0A1U7TT34_TARSY
Original site: A0A1U7TT34_TARSY 
ID   A0A1U7TT34_TARSY        Unreviewed;       467 AA.
AC   A0A1U7TT34;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   18-SEP-2019, entry version 16.
DE   SubName: Full=gamma-aminobutyric acid receptor subunit rho-3 {ECO:0000313|RefSeq:XP_008059563.1};
GN   Name=GABRR3 {ECO:0000313|RefSeq:XP_008059563.1};
OS   Tarsius syrichta (Philippine tarsier).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Tarsiiformes; Tarsiidae; Carlito.
OX   NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008059563.1};
RN   [1] {ECO:0000313|RefSeq:XP_008059563.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   RefSeq; XP_008059563.1; XM_008061372.1.
DR   GeneID; 103263699; -.
DR   CTD; 200959; -.
DR   OrthoDB; 480926at2759; -.
DR   Proteomes; UP000189704; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189704};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_008059563.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    467       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010564254.
FT   TRANSMEM    267    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    333    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       68    266       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      274    364       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      401    424       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   467 AA;  54438 MW;  A63C90FC87853967 CRC64;
     MVLAFQLVSF TYIWIVLMPN ACAASDSKNT HQRCFPSLKP TRKQEIRMWK DDNTKARPLK
     YETFLQIEDH DFAMRPGFGG SPVPVGIDVQ VESIDSISEA NMDFTMTFYL RHYWKDERLS
     FPSKTNKSMT FDHRLIKKIW VPDVFFVHSK KAFIHDTTME NIMLRVHPDG NVLFSLRVTV
     SAMCFMDFSR FPLDTQNCSL ELESYAYNEE DLMLYWKHGN KSLNTEEYIS LSQFFVEEFS
     ASSGFAFYSS TGWYNRLFIN FVLRRHIFFF VLQIYFPAML MVMLSWVSFW IDRRAVPARV
     SLGITTVLTM STIIIAVSTS MPHVSYIKAV DVYLWVSSLF VFLSVIEYAA VNYLTTVEER
     KKFKKRGKIS EMYNSDAVQA MAFDGCYHDS KTDLDQSSFS LHSEDSMRRK SIGSPSTDSA
     RVKRRKSLGE QVGRIILENN HVIDTYSRIL FPIVYIIFNL FYWGIYV
//
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