ID A0A1U7U1H5_CARSF Unreviewed; 440 AA.
AC A0A1U7U1H5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
GN Name=LCAT {ECO:0000313|RefSeq:XP_008063935.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008063935.1};
RN [1] {ECO:0000313|RefSeq:XP_008063935.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008063935.1; XM_008065744.1.
DR AlphaFoldDB; A0A1U7U1H5; -.
DR STRING; 1868482.ENSTSYP00000000042; -.
DR Ensembl; ENSTSYT00000000044; ENSTSYP00000000042; ENSTSYG00000000045.
DR GeneID; 103268200; -.
DR KEGG; csyr:103268200; -.
DR CTD; 3931; -.
DR OMA; PWQWVPL; -.
DR OrthoDB; 353098at2759; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:Ensembl.
DR GO; GO:0034186; F:apolipoprotein A-I binding; IEA:Ensembl.
DR GO; GO:0004607; F:phosphatidylcholine-sterol O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0047179; F:platelet-activating factor acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0004771; F:sterol esterase activity; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
DR GO; GO:0090107; P:regulation of high-density lipoprotein particle assembly; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|RefSeq:XP_008063935.1};
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transferase {ECO:0000313|RefSeq:XP_008063935.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..440
FT /note="Phosphatidylcholine-sterol acyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010528175"
FT TRANSMEM 199..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 440 AA; 49992 MW; B6033A228B7F03AC CRC64;
MGPPGSPWQW VLLLLGLLLP PAAPFWLLNV LFPPHTTPKA ELSNHTRPVI LVPGCLGNQL
EAKLDKPHVV NWMCYRKTED FFTIWLDLNM FLPLGVDCWI DNTRVVYNRT SGHVSNAPGV
QIRVPGFGKT YSVEYLDSNK LAGYMHTLVQ NLVNNGYARD ETVRAAPYDW RLEPSQQEEY
YRKLAGLVEE MHAAYGKPVF LIGHSLGCLH LLYFLLRQPQ SWKDRFIDGF ISLGAPWGGS
IKPMLVLASG DNQGIPIMSS IKLREEQRIT TTSPWMFPSQ MAWPEDHVFI STPNFNYTGR
DFQRFFVDLR FEEGWYMWLQ TRDLLSGLPA PGVEVYCLYG VGQPTPSTYI YDHGFPYTDP
VGVLYEDGDD TVATRSTELC GLWRERQPQP VHLLPLHGTQ HLNMVFSNQT LEHINTILLG
AYRRSTPVSP TASPEPLSPE
//
