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Database: UniProt
Entry: A0A1U7U4L4_TARSY
LinkDB: A0A1U7U4L4_TARSY
Original site: A0A1U7U4L4_TARSY 
ID   A0A1U7U4L4_TARSY        Unreviewed;      2671 AA.
AC   A0A1U7U4L4;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   13-FEB-2019, entry version 12.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|RefSeq:XP_008065020.1};
GN   Name=ITPR3 {ECO:0000313|RefSeq:XP_008065020.1};
OS   Tarsius syrichta (Philippine tarsier).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Tarsiiformes; Tarsiidae; Carlito.
OX   NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008065020.1};
RN   [1] {ECO:0000313|RefSeq:XP_008065020.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   RefSeq; XP_008065020.1; XM_008066829.1.
DR   GeneID; 103269243; -.
DR   CTD; 3710; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000189704; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189704};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_008065020.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2201   2226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2238   2256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2268   2288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2324   2349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2369   2391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2498   2521       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2629   2656       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2671 AA;  303940 MW;  398AE06BC4746CA0 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP TAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR SGRRNAGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSL VPRNSYVRLR HLCTNTWIQS TNVPIDVEEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIMVAK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE
     LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK
     NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY
     LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA
     MLQAYEDSSG KNVRRSIQGV GHMMSTMVLS RKQSVFGAPS LPAGPGAAEP LDRSKFEENE
     DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT
     ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLI HLTMHDYPPL VSGALQLLFK
     HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEVE
     AGAAKDKKER PADEEGFLHP PGEKSSENYQ TVKGILERLN KMCGVGEQMR KKQQRLLKNM
     DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKNL HLFLTPGLLE
     AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM
     IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN
     VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL
     FENFTLDMAR VCSKREKRLA DPTLEKYVLT VVLDTINAFF SSPFSENSTS LQTHQTIVVQ
     LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAISL PMDLDAHISV LLSSGASSAA
     AAQRNACSYK AATRTFPRVT PAANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDV
     LHWPELLFLE GSEAYQRCES GGFLSKLIQH TKDLMEPEEK LCIKVLRTLQ QMLRKKTKYG
     DRGNQLRKML LQNYLQNRKS SSRGDLPDPM GTGLDQDWSA IAATQCRLDK EGATKLVCDL
     ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET
     KSTVAVNMNN LGGQPREDRE PADPTAKGRV ASFSLPSSSS RYSLGPSLRR GHEVGERVQS
     NEMGISVLIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDIMCGSTTG
     GLGLLGLYIN EDNVGLVIQT LETLTEYCQG PCHENQTCIV THESNGIDII TALVLNDISP
     LCKYRMDLVL QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE
     NSEVSPREVG HNIYILALQL SRHNKQLQHL LKPVRRIQEE EAEGISSMLS LNNKQLSQML
     KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PAICQFLTEE TKHRLFTTTE
     QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR MTLWGSISFN LAVFINIIIA
     FFYPYVEGAS TGVLGSPLIS LLFWILICFS IAALFTKRYS IRPLIVALIL RSIYYLGIGP
     TLNILGALNL TNKIVFVVSF VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFAHELF
     YSILLFDLIY REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD
     RLPDNHSRAS PLGMPHGAAA FVGTCSGDKM DCVSGVSVTK VLEEDEELDS TERACDTLLM
     CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF FFIVIIIVLN LIFGVIIDTF
     ADLRSEKQKK EEVLKTTCFI CGLERDKFDN KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK
     TDYTGPESYV AQMIKNKNLD WFPRMRAMSL VSNEGEGEQN EIRILQDKLS STMKLVSHLT
     AQLNELKEQM TEQRKRRQRL GFVDVQNCMS R
//
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