UniProt: A0A1U7UST3

Database: UniProt
Entry: A0A1U7UST3_NICSY

LinkDB:  A0A1U7UST3_NICSY 
Original site:  A0A1U7UST3_NICSY

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Ontology (2)   
   GO (2)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (9)   

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ID   A0A1U7UST3_NICSY        Unreviewed;       817 AA.
AC   A0A1U7UST3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC104211733 {ECO:0000313|RefSeq:XP_009759132.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009759132.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT   tomentosiformis.";
RL   Genome Biol. 14:R60.1-R60.17(2013).
RN   [2] {ECO:0000313|RefSeq:XP_009759132.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009759132.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_009759132.1; XM_009760830.1.
DR   AlphaFoldDB; A0A1U7UST3; -.
DR   STRING; 4096.A0A1U7UST3; -.
DR   GeneID; 104211733; -.
DR   KEGG; nsy:104211733; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000189701; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF113; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        421..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        465..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        546..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        578..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        630..653
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        754..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          97..126
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   817 AA;  93227 MW;  67B401532383A160 CRC64;
     MEYIDNMPPM DLMRSEKMTF VQLIIPFESA HRAVTYLGQL GLLQFRDLNA EKSPFQRTFV
     NQVKRCAEMS RKLRYFKDQI HKAGLLPPPL PASQPDIELE ELEIQLAEHE HELIEMNANS
     EKLRQSYNEL LEFKMVLQKA SGFLVSSSHT TDQETELVEN VYSNDNHADT ASLLEQEMRS
     ELSNQSGVRF MSGIICKSKV VQFERMLFRA TRGNMLFNQA VADDEILDPS SNEMVEKVVF
     VVFFSGEQAR TKILKICEAF GANCYPVPED TTKRRQITQE VLFRLSELET TLDAGLRHRD
     KALTSIGYHL TKWINMVKTQ KAVYDTLNML NFDVTKKCLV GEGWCPIFAK TKIQEALQRG
     TFDSSSQVGI IFHVMDAVES PPTYFRTNSF TNAFQEIVDA YGVAKYQEAN PAVYTIVTFP
     FLFAVMFGDW GHGICLLLGA LVLIARESKL SSQKLGSFME MLFGGRYVLL LMSIFSIYCG
     LIYNEFFSVP FHIFGDSAYK CRDATCSDAR TVGLVKYNDP YPFGVDPSWR GSRSELPFLN
     SLKMKMSILL GVAQMNLGII LSYFNARFFS SSIDIKYQFI PQIIFLNSLF GYLSLLILVK
     WCTGSQADLY HVMIYMFLSP FEALGENRLF WGQSVLQVIL LLLALVAVPW MLFPKPFILK
     SLHMERFQGR TYGILGTSEM VIDEEPGSAS QHAEEFNFSE VFVHQMIHSI EFVLGAVSNT
     ASYLRLWALS LAHSELSTVF YEKVLLLAWG YDNIVIRLVG LAVFAFATTF ILLMMETLSA
     FLHALRLHWV EFQNKFYHGD GYKFKPFSFA LLADDDD
//

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