ID A0A1U7V2V0_NICSY Unreviewed; 390 AA.
AC A0A1U7V2V0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Alcohol dehydrogenase-like 7 {ECO:0000313|RefSeq:XP_009762562.1};
GN Name=LOC104214572 {ECO:0000313|RefSeq:XP_009762562.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009762562.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009762562.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009762562.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR RefSeq; XP_009762562.1; XM_009764260.1.
DR AlphaFoldDB; A0A1U7V2V0; -.
DR SMR; A0A1U7V2V0; -.
DR STRING; 4096.A0A1U7V2V0; -.
DR GeneID; 104214572; -.
DR KEGG; nsy:104214572; -.
DR eggNOG; KOG0022; Eukaryota.
DR OrthoDB; 451143at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF31; ALCOHOL DEHYDROGENASE-LIKE 7; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 44..171
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 214..345
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 390 AA; 42507 MW; E365DBBB2B6119BE CRC64;
MASTKQNGIS KTAGKPIRCR AAVARKPGEA LVIEEVIVAP PKAHEVRLKI ICTSLCYSDI
TFWKMKEFPG CFPRILGHEA FGIVESVGED VEELKEGDSV VPIFLSDCKE CVDCKSEKSN
LCSKFPFEVS PLLHRDETSR FTTVEGETLH HFLYISSFSE YTVVDITNVT KIDPEIPPNR
ACLFSCGVST GVGAAWKTAN VEPGSTVVIF GLGAIGLAVA EGARLCGATR IIGVDINSDK
FEIGKQFGVT DFINSNSCGD KPISQVIIEM TNGGADYCFE CVGLGTLVQE AFACCRKGWG
KTVVLGVDKP GAQLNLNSFE VLTSRKTLTG ALFGGLKPKS DVPILVKRYL DKELQLDKFV
THEVNFEDIN KAFDLLIQGK SLRCVIWMDK
//
