ID A0A1U7V886_NICSY Unreviewed; 1249 AA.
AC A0A1U7V886;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=ABC transporter B family member 19 {ECO:0000313|RefSeq:XP_009758464.1};
GN Name=LOC104211153 {ECO:0000313|RefSeq:XP_009758464.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009758464.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009758464.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009758464.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_009758464.1; XM_009760162.1.
DR AlphaFoldDB; A0A1U7V886; -.
DR GeneID; 104211153; -.
DR KEGG; nsy:104211153; -.
DR eggNOG; KOG0055; Eukaryota.
DR OrthoDB; 5487044at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24222; ABC TRANSPORTER B FAMILY; 1.
DR PANTHER; PTHR24222:SF76; MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTA; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 35..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..327
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 362..598
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 685..972
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1009..1243
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1249 AA; 136060 MW; 83829386C1C7A6B6 CRC64;
MAETTEGKPM PEAEKKKEQS LPFYQLFSFA DKYDYLLMIS GSIGAIIHGS SMPVFFLLFG
EMVNGFGKNQ MDLHKMVHEV SKYALYFVYL GLIVCASSYA EIGCWMYTGE RQVSALRKKY
LEAVLKQDVG FFDTDARTGD IVFSVSTDTL LVQDAISEKV GNFIHYLSTF LAGLVVGFVS
AWRLALLSVA VIPGIAFAGG LYAYTLTGLT SKSRESYANA GIIAEQAIAQ VRTVYSYVGE
SKALNSYSDA IQNTLKLGYK AGMAKGLGLG CTYGIACMSW ALVFWYAGVF IRNGQSDGGK
AFTAIFSAIV GGMSLGQSFS NLGAFSKGKA AGYKLMEIIK QKPTIVQDLA DGKCLSEVNG
NIEFKNVTFS YPSRPDVIIF RDFCIFFPAG KTVAVVGGSG SGKSTVVSLI ERFYDPNEGQ
VLLDNVDIKT LQLRWLRDQI GLVNQEPALF ATTILENILY GKPDATMAEV EAATSAANAH
SFITLLPNGY NTQVGERGVQ LSGGQKQRIA IARAMLKNPK ILLLDEATSA LDAGSESIVQ
EALDRLMVGR TTVVVAHRLS TIRNVDSIAV IQQGQVVETG THEELIAKGG AYSSLIRFQE
MVGNRDFSNP STRRTRSSRL SSSLSTKSLS LRSGSLRNLS YSYSTGADGR IEMISNAETE
RKNPAPQGYF CRLLKLNAPE WPYSIMGAVG SVLSGFIGPT FAIVMSNMIE VFYYRNPASM
ERKTKEYVFI YIGAGLYAVV AYLIQHYFFS IMGENLTTRV RRMMLAAILR NEVGWFDEEE
NNSSLLAARL ATDAADVKSA IAERISVILQ NMTSLLTSFI VAFIVEWRVS LLILATFPLL
VLANFAQQLS LKGFAGDTAK AHAKTSMIAG EGVSNIRTVA AFNAQEKIIS LFSQELRVPQ
MQSLRRSQMS GLLFGISQLA LYASEALILW YGAHLVSKGV STFSKVIKVF VVLVITANSV
AETVSLAPEI VRGGEAVGSV FSILDRSTRV DPDDTEADPV ESIRGDIELR HVDFAYPSRP
DVSVFKDFNL RIRAGQSQAL VGASGSGKSS VIALIERFYD PTGGKVMIDG KDIRRLNLKS
LRLKIGLVQQ EPALFAASIF ENIAYGKEGA TEAEVVEAAR AANVHTFVSG LPEGYKTPVG
ERGVQLSGGQ KQRIAIARAV LKDPSILLLD EATSALDAES ECVLQEALER LMRGRTTVLV
AHRLSTIRHV DSIGVVQDGR IVEQGSHSEL ISRPEGAYSR LLQLQHHRI
//
