ID   A0A1U7V8J7_NICSY        Unreviewed;      1199 AA.
AC   A0A1U7V8J7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=ARF guanine-nucleotide exchange factor GNOM-like {ECO:0000313|RefSeq:XP_009761281.1};
GN   Name=LOC104213471 {ECO:0000313|RefSeq:XP_009761281.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009761281.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT   tomentosiformis.";
RL   Genome Biol. 14:R60.1-R60.17(2013).
RN   [2] {ECO:0000313|RefSeq:XP_009761281.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009761281.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_009761281.1; XM_009762979.1.
DR   AlphaFoldDB; A0A1U7V8J7; -.
DR   STRING; 4096.A0A1U7V8J7; -.
DR   GeneID; 104213471; -.
DR   KEGG; nsy:104213471; -.
DR   eggNOG; KOG0928; Eukaryota.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000189701; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF350; ARF GUANINE-NUCLEOTIDE EXCHANGE FACTOR GNOM-LIKE; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT   DOMAIN          311..500
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          11..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          672..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        683..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|RefSeq:XP_009761281.1"
SQ   SEQUENCE   1199 AA;  134454 MW;  3054484F8FCC2423 CRC64;
     VVGLDNEYSF NSKSENGTGT SEYDSQPPSG AFSSSASTVV LNGVIDEGMI MSDNGKDNVP
     NDLHLMTEPY GVPCMVEIFH FLCSLLNVVE HIGMGPRANT TAFDEDVPLF ALCLINSAVE
     LGGSAIRSHP RLLSLVQDEL FQNLMVFGLS TSPVILSTVC GIVLNLYQHL RNELKLQLEA
     FLSCVVLRLA QSRYGASYQQ QEVAMEALVD FCRQKSFMVE MYANLDCDIT CTNVFEELAN
     LLSKSAFPVN SPLSAMNILA LDGLIAVIQG MAERISNGCS SQQIPINLEE YAPFWMVKCE
     SYSDPDHWVP FVRRRKYIKR RLMIGADHFN RDPKKGLEFL QGTHLLPEKL DPQSVACFFR
     FTAGLDKNLV GDFLGNHDEF CIQVLHEFAG TFDFEDMNLD IALRLFLETF RLPGESQKIQ
     RVLEAFSERY YEQSPQILAN KDAAMVLSYS VIMLNTDQHN VQVKKKMTEE DFIRNNRNIN
     GGNDLPREYL SELYHSICNN EIRTTPEQGA GFAEMNPSRW IDLMHKSKRT SPYIVCDLRA
     YLDHDMFATM SGPTIAAISV VFDHAEHEDV YQTCIDGFLA VAKISACHHL EDVLDDLVVS
     LCKFTTLLNP SLVEEPVLAF GDDAKARMAT VTVFTIANKY GNFIRTGWRN ILDCVLRLHK
     LGLLPARVAS DAADESEAPS DTGQGKPLPN SLSSTHMQSI GTPRRSSGLM GRFSQLLSLD
     TEEPRSQPTE QQLAAHHSTL QTIQKCHIDN IFTESKFLLA DSLLQLARAL IWVAGRPQKG
     SSSPEDEDTA VFCLELLIAI TLNNRDRIRL LWQGVYEHIA NIVHSTVMPC ALIEKAVFGL
     LRICLRLLPY KENLADELLR SLQLVLKLDA RVADAYCEQI TQEVSRLVKA NATHIRSQMG
     WRTITLLLSI TARHPEASEA GFDALVFIMS DGAHLSPANY VLCLDAARNF AESRVGPADR
     PARAVDLMAG SVACLARWSK DTREALAETE AVKLSHDIGE MWLRLVQGLR KVSLDQREVR
     NHALSSLQMC LTGEHEIYFP HGLWLQCFDM VLFTMLDDLI ELASQKDYRN MEETLVLALK
     LLTKLFHQLF HELSQLTTFC KLWLGVLNRM EKCMKVKVRG KKSEKLQELV PELLKNTLSV
     MKSKGVLVKR SALGGDSLWE LTWLHVNNIV PSLQSEVFPD IDSENLQPDP VSVETDPNE
//