ID A0A1U7V9F9_NICSY Unreviewed; 2266 AA.
AC A0A1U7V9F9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Acetyl-CoA carboxylase 1-like {ECO:0000313|RefSeq:XP_009758450.1};
GN Name=LOC104211137 {ECO:0000313|RefSeq:XP_009758450.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009758450.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009758450.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009758450.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR RefSeq; XP_009758450.1; XM_009760148.1.
DR STRING; 4096.A0A1U7V9F9; -.
DR GeneID; 104211137; -.
DR KEGG; nsy:104211137; -.
DR eggNOG; KOG0368; Eukaryota.
DR OrthoDB; 911at2759; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-KW.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Chloroplast {ECO:0000256|ARBA:ARBA00022528};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Plastid {ECO:0000256|ARBA:ARBA00022528};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 47..554
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 200..392
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 681..755
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1505..1844
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1848..2163
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2266 AA; 252624 MW; 941029BB50334F4C CRC64;
MSEAQRMPTM IRIKSGNGHV NGALPLRSPM ARAEVAEFCN ALGGKRPINS ILIANNGMAA
VKFIRSIRTW AYETFGTEKA ILLVAMATSE DMRINAEHIR IADQFVEVPG GTNNNNYANV
QLIVEMAEMT HVDAVWPGWG HASENPELPD ALNAKGIIFL GPPATSMAAL GDKIGSSLIA
QAAEVPTLPW SGSNVKVPPE SSLVSIPDEI YAKACVHTTE EAIASCQDVG FPAMIKASWG
GGGKGIRKVH NDDEVRALFK QVQGEVPGSP IFIMKVASQS RHLEVQLLCD QYGNVAALHS
RDCSVQRRHQ KIIEEGPITV APQDTVKKLE QAARRLAISV NYVGAATVEY LYSMDTGEYY
FLELNPRLQV EHPVTEWIAE INLPAAQVAV GMGIPLWQIP EIRRFYGMEH GAGYDAWRKT
SIAATPFDFD KAESTRPKGH CVAVRVTSED PDDGFKPTSG KVQELSFKSK PNVWAYFSVK
SGGGIHEFSD SQFGHVFAFG ESRALAIANM VLGLKEIQIR GEIRTNVDYT IDLLHASDYR
ENKIHTGWLD SRIAMRVRAE RPPWYLSVVG GALYKASASG AALVSEYIGY LEKGQIPPKH
ISLVSSQVSL NIEGSKYTIN MVRGGPGSYR LRMNESEIEA EIHTLRDGGL LMQLDGNSHV
IYAEEEAAGT RLLIDGRTCL LQNDHDPSKL IAETPCKLLR YLMSDGSHVD ADTPYAEVEV
MKMCMPLLSP ASGVIHFKMS EGQAMQAGEL IASLDLDDPS AVRKAEPFRG SFPILEPPTA
ISGKVHQRCA ASLNATRMIL AGYDHNVDDV VHNLLSCLDS PELPFLQWQE CLSVLATRLP
KDLRYELEAK YKEYEGISGL QTVDFPARIL RGVLEAHLRT CSEKEKGAQE RLVEPLMSLV
KSYEGGRESH ARGIVHSLFE EYLTVEELFS DNIQADVIER LRLQYKKDLL KVVDIVLSHQ
GVRRKNKLIL SLMEQLVYPN PAAYREKLIR FSALNHTNYS ELALKASQLL EQTKLSELRS
SIARNLSELE MFTEEGDSMD TPKRKSAINE RMEVLVSAPL AVEDALVGLF DHSDHTLQRR
VVETYIRRLY QPYLVQGSVR MQWHRSGLIA TWQFMEEHVE RKSGSGGDNV IVKPLVEKHS
ERKWGAMVII KSLQLLPTVL NSALRETAHD LHAEMSNGST QPVSHGNMLH IALVGINNQM
SLLQDSGDED QAQERIYKLA KILRDKDASA SLKSAGVGVI SCIIQRDEGR VPMRHSFHWS
TEKLYYEEEA LLRHLEPPLS IYLELEKLKI YDNIKYTPSR DRQWHLYTVV DKQNPIQRMF
LRTLVRQPTD DGLLAYQGLN QGTAHSSLNL PFTSRSILRS LISALEELEL NLHNSTLKAD
HAHMYLYILR EQEFDDLLPY HKRADVNNEH KEAEVQKILE ELAHEINASV GVRMHRLGVC
EWEVKLWISS AGDATGAWRI VVANVTGHTC IVHIYREVED TGVQRVVYHS AIGHGPLNGV
PVTAPYPPLA VLDQKRLLAR KNDTTYCYDF PLAFKAALEK SWASHNPGTD KPKDNVLLKV
TELTFVDKKG SWGTPLVPVE RQPGFNDVGM VAWIMEMSTP EFPTGRKILV VANDVTFING
SFGPSEDAFF QAVTGVSCTQ KLPLIYLAAN SGARIGAAEE VKSCFKVGWS DESNPERGFQ
YIYLIPEDHE RIKSSVMAHE LKLSNGEVRW VIDTIIGEED GLGVENLSGS GAIASAYSRA
YHETFTLTYV TGRTVGIGAY LARLGMRCIQ RLDQPIILTG YSALNKLLGR EVYSSHMQLG
GPKIMGTNGV VHLTVSDDLE GISKILNWLS FVPPYSGGPL PISTPLDPPQ RPVEYFPETA
CDPRAAISGH TDASGKWLGG IFDKDSFIET LEGWARTVVT GRAKLGGIPV GIVAVETQTM
MQVIPADPGQ LDSHERVVPQ AGQVWFPDSA TKTAQALMDF NREELPLFIL ANWRGFSGGQ
RDLFEGILQA GSTIVENLRT YKQPVFVYIP MMGELRGGAW VVVDSKINSD HIEMYAERTA
KGNVLEPEGM IEIKFRTKEL LECMGRLDQQ LINLKLKLQE ARTAGVYTNV EALQQQIKTR
ETQLLPVYTQ IATKFAELHD TSLRMAAKGV IREVVNWETS RSFFYRRLLR RVEEEMLVKT
VRNAAGDQLS YKSAMDMVKT WFLDSKGGKV DSWIDDEAFF SWKNDPKNYE EQLQQLRVQK
VLVQLSKIGD STLDLRALPQ GLLSLLQKVE PATREQLISD LKKLLN
//