ID A0A1U7VFE1_NICSY Unreviewed; 469 AA.
AC A0A1U7VFE1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial-like {ECO:0000313|RefSeq:XP_009761044.1};
GN Name=LOC104213277 {ECO:0000313|RefSeq:XP_009761044.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009761044.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009761044.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009761044.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_009761044.1; XM_009762742.1.
DR AlphaFoldDB; A0A1U7VFE1; -.
DR SMR; A0A1U7VFE1; -.
DR STRING; 4096.A0A1U7VFE1; -.
DR GeneID; 104213277; -.
DR KEGG; nsy:104213277; -.
DR eggNOG; KOG1182; Eukaryota.
DR OrthoDB; 952at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR43380:SF12; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA 1, MITOCHONDRIAL-LIKE; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 132..429
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 469 AA; 53015 MW; 332B7313754DF0F8 CRC64;
MANWVVRSRS WLNHFVLSSR RTSCSGILRK QPVAFSGEST TVLVSRRFDS IEAGQKLDPC
SYEEDYHSDT AHENQDLDFP GGKIPLTSEM KFISEASDIR LPCYRVLNDD GSLISDSIYE
QVGQELAVNM YTAMVTLKTM DTFLYEAQRQ GRISFYMTCC GEEAINIASA AALSPHDFVL
PQYRESGVLL WRGFTVQECT NQCFGNKDDK GKGRQMPVHY GSKKHNVITI SSPLATQISQ
AAGVAYSLKM DKRGACTVVY TGEGGTSEGD FHAGLNFAAV MEAPVIFICR NNGWAISTPV
YEQFRSDGIV TKGIGYGIRS IRVDGNDAIA VYSAIHAARN MAINENRPIL VEAMTYRVGH
HSTSDDSTRY RPTNEIEYWK TARSPIARFR KWIQRNGWWS DDKESELYRN TKKQVLQAIE
RAEKMEKPPL TELFTDVYDQ MLPNLQEQER SLRDTFKKHS TDYPTDVHV
//
