ID   A0A1U7VPN0_NICSY        Unreviewed;       877 AA.
AC   A0A1U7VPN0;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE            EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN   Name=LOC104216043 {ECO:0000313|RefSeq:XP_009764304.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009764304.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT   tomentosiformis.";
RL   Genome Biol. 14:R60.1-R60.17(2013).
RN   [2] {ECO:0000313|RefSeq:XP_009764304.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009764304.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC       {ECO:0000256|ARBA:ARBA00007476}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_009764304.1; XM_009766002.1.
DR   AlphaFoldDB; A0A1U7VPN0; -.
DR   STRING; 4096.A0A1U7VPN0; -.
DR   GeneID; 104216043; -.
DR   KEGG; nsy:104216043; -.
DR   eggNOG; KOG1157; Eukaryota.
DR   OrthoDB; 1396at2759; -.
DR   Proteomes; UP000189701; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Plastid {ECO:0000256|ARBA:ARBA00022640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT   DOMAIN          160..276
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   877 AA;  97180 MW;  0DD377680ACD5F3B CRC64;
     MRSCQNSTMF CHKRALILRK NPLLLYFPCC QGLRRNAKFR CVLDQIVPKF AVSSSLSSVL
     TSGNAIAAAA AVAGTGSLHG AVSSAITQVA VTAVAIASGA CLSTKVDFLW PKVDEQPGSL
     LLDGVDVTGY PIFNDDKVQK AIAFARKAHH GQLRRTGEPY LTHCIHTGKI VAVLVPSTGK
     RAIDTVVAGI LHDVIDDTSE SLDTIEREFD TDVANLVAGV SRLSYINQLL RRHRRLNENQ
     AALSQEEANS LRVMLLGMVD DPRVVLIKLA DRLHNMRTIY ALPPAKAQAV AQETLAIWCS
     LASRLGLWAL KAELEDLCFA VLQPQIFLRM RADLASMWSH PNRTGNARKI YGKSSSLLHQ
     RMKSMAAEHE EPAETDEEYI CMKVLLQAVL PFELLLDRKK RIDFFNKLVA NSNLETKPKV
     VRDAAFALGS LVVCEEALER ELFISTSYVP GMEVTLSGRL KSLFSIYSKM KRKEIGINKV
     YDARALRVIV GDKNGALHSQ AVQCCYNLLN IVHRLWSPID GEFDDYIVNP KPSGYQSLHT
     AVQGPDNSPL EIQIRTQRMH ECAEHGLAAH WLYKETEDKL PLETSVTGSG TTTPSYFSTD
     IEDEGSIVDD GSHKYSSLKV GHPVLRVEAG HLLAAVIVRV DKDARELLVA VSFGLAASEA
     VADRRSSSQT KRWEAYASLY KKVSDEWWFE PGHGDWCTCL EKYTLCQDGM YHKQDQFQRM
     LPTFIQIIEL TEEEENLYWA IMSAVFEGKP VASVTSNPSF QNNPGYSSAN STLMDSGINN
     KVYLLRTMLQ WEKQLRSEAS LQRVEYATKT YDASSGLLGE VVIVCWPNGE IMRLSTGSTA
     ADAARRAGVE GKLVSVNGQL VVPNTKLRDG DVVEIRM
//