ID A0A1U7W256_NICSY Unreviewed; 338 AA.
AC A0A1U7W256;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Methyl-CpG-binding domain-containing protein 2-like isoform X1 {ECO:0000313|RefSeq:XP_009768693.1, ECO:0000313|RefSeq:XP_009768698.1};
GN Name=LOC104219682 {ECO:0000313|RefSeq:XP_009768693.1,
GN ECO:0000313|RefSeq:XP_009768698.1, ECO:0000313|RefSeq:XP_009768707.1,
GN ECO:0000313|RefSeq:XP_009768714.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009768714.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009768693.1, ECO:0000313|RefSeq:XP_009768698.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009768693.1,
RC ECO:0000313|RefSeq:XP_009768698.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_009768693.1; XM_009770391.1.
DR RefSeq; XP_009768698.1; XM_009770396.1.
DR RefSeq; XP_009768707.1; XM_009770405.1.
DR RefSeq; XP_009768714.1; XM_009770412.1.
DR STRING; 4096.A0A1U7W256; -.
DR GeneID; 104219682; -.
DR KEGG; nsy:104219682; -.
DR eggNOG; KOG4161; Eukaryota.
DR OrthoDB; 1217115at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR Gene3D; 3.30.40.100; -; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR12396:SF0; METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C; 1.
DR PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 115..174
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DOMAIN 180..254
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 38238 MW; 6263637E3D11D37E CRC64;
MERDHLDLAT LGKTDHNDIH GSSVASHRDN MKYEPKDLRN SADPAFNQNP IDVTSSPERE
DHSTDDEDNQ GEDAQKQLVL YDPAAVGAGE IELVPDPLDS QPRRNSFPNY TSRILPAVGA
FTVQCANCFK WRLIPSKEKY EKIREHILEQ PFYCETAREW RAGVSCDDPP DLTQDGSRLW
AIDKPNIAQP PPGWERLLRI RGEGGTRFAD VYYVSPSGKR LRSMIEIQKY LQEHPEYVAE
GVSMSRFSFQ IPRPLQENYV RKRPYRPALA HDEDDPAMAV KRISWIGSDG GTDLRLGMPG
LSAPIYRAPL FEPVSQSLKK KRTPSKRMSN TDAACKSS
//
