ID A0A1U7W567_NICSY Unreviewed; 875 AA.
AC A0A1U7W567;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN Name=LOC104222754 {ECO:0000313|RefSeq:XP_009772346.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009772346.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009772346.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009772346.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR RefSeq; XP_009772346.1; XM_009774044.1.
DR AlphaFoldDB; A0A1U7W567; -.
DR STRING; 4096.A0A1U7W567; -.
DR GeneID; 104222754; -.
DR KEGG; nsy:104222754; -.
DR eggNOG; KOG1096; Eukaryota.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF14; AMP DEAMINASE; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
SQ SEQUENCE 875 AA; 101158 MW; 78DD939EB24D1A10 CRC64;
MEPWLSTSAS QMQLALAALF GASVMAISAF YLHKRSVDEV LERLIKLRRK RHHTFSASDS
ETEDFGIYED DEIDNVSTRN VYSSNLSKEP IDNADDDDCY DDNVLRSYRV SSSMPNVRVS
NQWMDEESSF DRTVQCADKK PSSNSVENPS LIPSSGDERF VRVESVVKPT TPKFSSDCAF
ESVGNSNEDK GECAAAEDAV FSYDNDISPT EEEFSISALK AENRIHLQHI AVAPEARSNI
DHDVGELDRA SMHIVENDPS FFNNILPLPT AAHDPMNVEE EEVLKMICEC LDLRDKYVFR
EEIAPWMKEN MSKSKASDKK HDPFSFAQFE ATSHQFKMED GVVRVYATEN DTEELFPVAS
ATTFFTDMHH LLKVMAVGNV RSYCHHRLRF LEEKFRLHLL VNADREFLAQ KSAPHRDFYN
IRKVDTHVHH SACMNQKHLL RFIKSKLRKE PDEVVIFRDG QYLTLKEVFE SLDLTGYDLN
VDLLDVHADK STFHRFDKFN LKYNPCGQSR LREIFLKQDN LIQGRFLAEV TKEVLQDLEA
SKYQLAEYRI SVYGRKQSEW DTLASWFVNN ELYSQNAVWL IQLPRLYNVY RSMGTCTSFQ
NILDNVFVPL FEVTVDPKSH PHLHMFLMQV VGFDMVDDES KPERRPTKHM PTPDEWTNQF
NPAFSYYAYY CYANLYTLNK LRESKGLPTI RFRPHCGEAG DIDHLAAGFL LCHNISHGIN
LRKTPVLHYL YYLAQVGLAM SPLSNNSLFL DYNRNPFLMF FHRGMNVSLS TDDPLQIHLT
KEPLVEEYSV AAKVWKLSSC DLCEIARNSV YQSGFKHADK AHWLGCKYYK RGPQGNDIHK
TNVPNMRISF RHETWKEEMH YVYRGKAILP EDVEH
//
