ID A0A1U7W7Z6_NICSY Unreviewed; 2812 AA.
AC A0A1U7W7Z6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Serine/threonine-protein kinase ATM isoform X4 {ECO:0000313|RefSeq:XP_009773326.1};
GN Name=LOC104223562 {ECO:0000313|RefSeq:XP_009773326.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009773326.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009773326.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009773326.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR RefSeq; XP_009773326.1; XM_009775024.1.
DR GeneID; 104223562; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR37079:SF6; -; 1.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_009773326.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1892..2545
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2651..2812
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 813..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2400..2434
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2812 AA; 319165 MW; 8B4218C1736858BD CRC64;
MVNTVTSRDI QDIVSKLSSD KAKSREEGIK LLNAWLEEGQ RSVEFCRYVG EKTARLKPGE
IPHSETWPFL VTLLTKCVSL EISGSKKRLP KLNFAKTLRI VVQRAEDAKF SGKDMPLLPV
AKLLFNHVWD VLKDTPSFQS EYGTILRHLL AVRSYRFHMR KRVYCCLVLL YMEKIETSLK
EKSDSQINPR EEVFRCISTL HSLLENPPGG FPDSLQEDIV KGFIEIFSYV RDEGKISRKL
IECINIYLLR DGPNLGSKSL EIHDALHHFV FRCWMTTRDR GLKDSLVFYA RLQLNLTRDF
ADGSSLLEQL QDVLGKELDQ MSSWTINLPW KDTTRNDKCG SLTSSQCGLM ELAALVFYRA
CLNTPIASSS EKRLRREHVV VQIRERLSRG KWPWHAAFCY LIHNYYGRIK KDLLIYWFEG
ICASFERIIN DANMEHSYEG LLWALRSLQG LSLMLRFPVP ALQTSSELAS TFNGVETGWR
TIWNCVIGGL PTFSTFTAVV DAALRLLRNI ILNDKMNAYL VPQDLWDLRL LKRVPSISVL
CFISCYFSRK GYQGDLRDAL HLRQNLLRAV LAVPFWKDCS MLNKQLVAIL PTAVYALCTG
GTPLLDKGLS PSHYVPEILN DVKVEDHTHE SEHEFFECSV EVLARIGHES DLEDVQSPGC
QSIRLPRQIR DPLCHEVENH ILEIIKDEEH EKMLLSDVIF LCAILSNFMY CSYSTRLGEE
IMPCLATLSQ YVSKLLDRAA SILEKSYDDL VCGLSGSRSI FDTIGTIGVS FESFLCSPLF
NEMQNDDNID VLAAVIQSVE RILKVLAKLY EGSSSSGSNF HSKRGDLDSS ASVSSHDSHP
VNSRTSMIMD MELDVNISSK DTDAVKIGGK ATAEILASSV NQRMEVVSII TKFFSALPFH
TWDVIFELME KESDPRVLEV IIHGLCQHPH WSSSRKFLNL VTSLNDFLDI QANLKVQSLN
VLAAICSLLE SLLSCEDVAK FKKSREKLSE EGLISLGDLV NKIADSDLFD WVGRTKLIDC
ICNFILVDPQ IGQSMIEKLL LMLRDADYRV RLCFAQRVGV LFQTWDGHFE LFQDICSNFG
TKLVTCSREK LVMAKEVLAA GPQPHTILET IIVTLAHLAL HSEKIELEAV FMVCVIAAIN
PCLRKLVIVV LDNLSRELKY TSRSKYMEEL MAPILFSWVA SGVNLAALLE ARDLFVFNVE
PINFIQSCCR WLLPSLFLHG DISNMNWLAK VACEPLAEMI KNHFVDIFSV CITLHSSKKA
GWEKGSAVLE SSILDIAKIS ETERDKLIKK HMVSIVNTIF SLASTAVDPV LPLFSKETIA
RAIMTVVDGF LEIDDSCQNF GLIDKINIFR PDRVFTFIVE MHYKVAAAGH FRHKSDRLAG
IEVLIDVLGH RVAVPSTASY LLNLIGQCLD LDALLDQCCR MISSLLKIFK IKQLEGTAVV
LGEQLQFLIS KLVMCCISSE SSPKLSADTS SQVLSLLSQL TLDSDPSLHE YIKELEPFPN
LDLFHDIRMF HEKLCQNYSP REHLSILGKR SRYLPPRLLV WSLKALHKKL FEDEAYPAQK
NEENIFEDAY LDSDHDIVHT VWNLVHTCSL SGAGNFGSLV SDFLSRVGIG DPHGVVFHLP
IQSKSVHEHN FHLDTGISDD LLVAIMRLLK KYLMDDSVKI IDIASQALRG ILSTENGQRA
LLSFDSYQRS LIEVHSKGVN VNLVQKLLAD LERKLNVEAL SLKDSAIWKT DGKTFETWIC
PLVCALVEYC DDMILRLCQD IVLVKSEVAE LLFPHVMVNL SSRRDVDVDL CQLISSQVQE
NIFTEDNKLT KSIQVILDAL NELRLCHVME RSTSSNPSKR ENAKQYGRPS SYGSKSRSTP
LKAKHQTTTS SVVSISTLSW EKVYWISMDY LAVARSAITS GAYFTAVLYV EHWCEENFNS
LTLGPPDFSH VEILPWHIEI LLSAVTQINE PDSLYGIIQS HKLTSQIITF EHEGNWSKAL
EYYDLQIRSD PVAQGSSCTP KNFLHSSGSA VDQMIEKKPY KGLIRSLQQI GCTHLLDVYC
QGLTSQKGRF QHDPEFTELQ YEAAWRSGNW DFSLLYGESS VLSIQHGGDH FNENLHSCLR
ALKEGGFDEF QIKLKDSKQE LLLSICHASA ESTKYIYQAI VKLQILYHLG MTWDSRWTSS
CTMLDSLKMP KVSSKPVLPS ITQLSWLDMD WKRTLKQAQL HMNLLEPFVA FRRVLLHILN
CQDYTVQHLL ESAATLRKVA RFSQAASALH EFKFLCAEMG EHSNLYWLGR LEEAKLLRAQ
GQHQMAINLA KYISLNHQTN ENASDVFRLI GKWLAETRSS NSRTILEKYL KHAVVLAEDC
MARGKVSAIK RSQLHFHLAH YADALFRSYE ERLNSSEWQA AMRLRKHKTR ELEALVKRLR
SSTKGEKTDL SAKIQELQKQ LAMDKEEAEK LQEDRDNFLS TALDEYKRCL VIGDKYDVRV
VFRLISLWFG LSFRPIVVDS MLGTISEVQS YKFIPLVYQI ASRMGSTKES QGAQNFQFAL
VSLIKRMAID HPYHTIFQLL ALANGDRIKD KQRSRSSFVV DMDKKAAAEN LLKELSSYHG
AVIRQMKQMV EIYIKLAELE TKREDTNKKV NLPREIRSIR DLELVPVVTA NIAIDPSCQY
TEGSFPHFKG LADSVTVMNG INAPKVVECF GSDGNKYRQL AKSGNDDLRQ DAVMEQFFGL
VNTFLQNHRD TWKRRLRIRT YKVVPFTPSA GVLEWVNGTL PLGEYLIGST RDGGAHGRYG
AGDWTFMKCR QHMTVAWVRI LVTELFSRLH KHVPKGRNSR EEKKCMIERQ GE
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