ID A0A1U7WBB2_NICSY Unreviewed; 565 AA.
AC A0A1U7WBB2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cation/calcium exchanger 1 {ECO:0000313|RefSeq:XP_009775933.1};
GN Name=LOC104225766 {ECO:0000313|RefSeq:XP_009775933.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009775933.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009775933.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009775933.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily.
CC {ECO:0000256|ARBA:ARBA00038187}.
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DR RefSeq; XP_009775933.1; XM_009777631.1.
DR AlphaFoldDB; A0A1U7WBB2; -.
DR STRING; 4096.A0A1U7WBB2; -.
DR GeneID; 104225766; -.
DR KEGG; nsy:104225766; -.
DR eggNOG; KOG2399; Eukaryota.
DR OrthoDB; 3087817at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF24; CATION_CALCIUM EXCHANGER 1; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..247
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 408..561
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 565 AA; 61588 MW; 196AE91F0020C9BF CRC64;
MDFFPFYFKP RSALSIFFNT SFLFILLLYT LTFNGFSQSQ THVHLSKTKI NDCSDLYKLI
DSQSKCAYIK SSTSCSGKGY VNYLEFFYCI LGWSPVLGHT LLLLWLVLLF YLLGNTAAEY
FCPSAEGLSK VMNLSPTIAG TTLLPLGNGA NDVISSIISF TRSSSGGVGL NSVLGGAFFV
SCVVVGVISI VVSPSHRLTI DKPSFIRDVL FIIFSLSCLL GIIVFGRVNL WIAICFSSIY
VIYICVVCTM HFFSKDEAAE NVNSTDKEDE LDNEIGVALL GCVDEEKSSE LCPNEKHTEE
INSSIFGTSS SFCKFINCFL GVLDFPLYLP RRLTIPVVSE DKWSKPMAVI SATLAPILAA
AVSSEGMDSP TSLAIGMTSV LVGLILGNLA FLSTKESSPP KECLLIWLLG GFLMSITWTY
VLAQELVSLL VSFGYIIGIN PSILGLTVLA WGNSTGDLIS NVAMALNGGK DGQQMAISAC
YAGPLFNTLI GLGVSLVFAS WWEYPVSYVL PKDPFLCETL GFLMVGLLWA LVILPKRNMQ
PDISLGVGLL AIYFCFLFLR FAKGF
//
