ID A0A1U7WBR2_NICSY Unreviewed; 1214 AA.
AC A0A1U7WBR2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC104222555 {ECO:0000313|RefSeq:XP_009772099.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009772099.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009772099.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009772099.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000256|ARBA:ARBA00008684}.
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DR RefSeq; XP_009772099.1; XM_009773797.1.
DR AlphaFoldDB; A0A1U7WBR2; -.
DR STRING; 4096.A0A1U7WBR2; -.
DR GeneID; 104222555; -.
DR KEGG; nsy:104222555; -.
DR eggNOG; ENOG502QRF2; Eukaryota.
DR OrthoDB; 385706at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 3.30.1490.310; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045381; BRI1_island_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48056; LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED; 1.
DR PANTHER; PTHR48056:SF18; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF20141; Island; 1.
DR Pfam; PF00560; LRR_1; 5.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|RefSeq:XP_009772099.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 807..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 895..1170
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 924
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1214 AA; 132961 MW; F0B00AD683117AD2 CRC64;
MKPHNSAMYQ HHFSLNKIFL LSFSLQPLFI LLLIIFFLPP ASPASVNGLF KDSQQLLSFK
SSLPNTQTQL QNWLSSTDPC SFTGVSCKNS RVSSIDLTNT FLSVDFTLVS SYLLGLSNLE
SLVLKNANLS GSLTSAAKSQ CGVSLNSIDL AENTISGPVS DISSFGACSN LKSLNLSKNL
MDPPSKELKA STFSLQDLDL SFNNISGQNL FPWLSSMRFV ELEYFSVKGN KLAGNIPELD
FKNLSYLDLS ANNFSTGFPS FKDCSNLEHL DLSSNKFYGD IGASLSSCGK LSFLNLTNNQ
FVGLVPKLPS ESLQFLYLRG NDFQGVFPSQ LADLCKTLVE LDLSFNNFSG LVPENLGACS
SLEFLDISNN NFSGKLPVDT LLKLSNLKTM VLSFNNFIGG LPESFSNLLK METLDVSSNN
ITGFIPSGIC KDPMSSLKVL YLQNNWFTGP IPDSLSNCSQ LVSLDLSFNY LTGKIPSSLG
SLSKLKDLIL WLNQLSGEIP QELMYLKSLE NLILDFNDLT GSIPASLSNC TNLNWISMSN
NLLSGEIPAS LGGLPNLAIL KLGNNSISGN IPAELGNCQS LIWLDLNTNF LNGSIPGPLF
KQSGNIAVAL LTGKRYVYIK NDGSKECHGA GNLLEFGGIR QEQLDRISTR HPCNFTRVYR
GITQPTFNHN GSMIFLDLSY NKLEGGIPKE LGSMYYLSIL NLGHNDFSGV IPQELGGLKN
VAILDLSYNR LNGSIPNSLT SLTLLGELDL SNNNLTGPIP ESAPFDTFPD YRFANTSLCG
YPLQPCGSVG NSNSSQHQKS HRKQASLAGS VAMGLLFSLF CIFGLIIVAI ETKKRRKKKE
AALEAYMDGH SNSVTANSAW KFTSAREALS INLAAFEKPL RKLTFADLLE ATNGFHNDSL
IGSGGFGDVY KAQLKDGSVV AIKKLIHVSG QGDREFTAEM ETIGKIKHRN LVPLLGYCKV
GEERLLVYEY MKYGSLEDVL HDRKKNGIKL NWHARRKIAI GAARGLAFLH HNCIPHIIHR
DMKSSNVLLD ENLEARVSDF GMARLMSAMD THLSVSTLAG TPGYVPPEYY QSFRCSTKGD
VYSYGVVLLE LLTGRTPTDS VDFGDNNIVG WVRQHAKLKI SDVFDRELLK EDPSIEIELL
QHFKVACACL DDRHWKRPTM IQVMAMFKEI QAGSGIDSSS TIAADDVNFS AVEGGIEMGI
SESIKEGNEL SKHL
//
