ID A0A1U7WE69_NICSY Unreviewed; 468 AA.
AC A0A1U7WE69;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cysteine proteinase RD21a-like {ECO:0000313|RefSeq:XP_009772520.1};
GN Name=LOC104222895 {ECO:0000313|RefSeq:XP_009772520.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009772520.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009772520.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009772520.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_009772520.1; XM_009774218.1.
DR AlphaFoldDB; A0A1U7WE69; -.
DR SMR; A0A1U7WE69; -.
DR STRING; 4096.A0A1U7WE69; -.
DR GeneID; 104222895; -.
DR KEGG; nsy:104222895; -.
DR eggNOG; KOG1543; Eukaryota.
DR eggNOG; KOG4296; Eukaryota.
DR OrthoDB; 5472443at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF962; CYSTEINE PROTEASE RD21C-RELATED; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022807};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..468
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018644256"
FT DOMAIN 50..106
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 138..354
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 377..434
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
SQ SEQUENCE 468 AA; 52167 MW; D0C6E502E8451611 CRC64;
MAFFRSFLFF LLTFFVLSSA LDMSIISYNE QHGQMGTTHH RTDDEVRGLY ESWLVKHGKN
YNAIGEKEKR FEIFKDNLRF IDEHNAENRS YKLGLNRFSD LTNEEYRAMF VGGRLDRKTR
LMKNPKSDRY TFQAGEKLPE SVDWREKGAV APVKDQGQCG SCWAFSTVGA VEGINKIVTG
ELISLSEQEL VDCDRSYNQG CNGGLMDYAF DFIKNNGGID TGDDYPYHAQ DGTCDPYRKN
ARVVSIDGYE DVPENDEKSL MKAVANQPVS VAIEAGGRAF QHYSSGVFTG YCGTQLDHGV
VVVGYGTENG EDYWIVRNSW GPNWGESGYI KLQRNFANST TGKCGIAMQA SYPLKSGANP
PNPGPSPPTP VTPPTVCDEY YSCPQGTTCC CIYQYGEYCF GWGCCPYESA TCCDDNYSCC
PHDYPVCDVD AGTCLMSKDN PLKVKALKRG PARANWSGMK SNRKVSYA
//
