ID A0A1U7WKA5_NICSY Unreviewed; 592 AA.
AC A0A1U7WKA5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Probable acyl-activating enzyme 1, peroxisomal {ECO:0000313|RefSeq:XP_009780397.1};
GN Name=LOC104229443 {ECO:0000313|RefSeq:XP_009780397.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009780397.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009780397.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009780397.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR RefSeq; XP_009780397.1; XM_009782095.1.
DR AlphaFoldDB; A0A1U7WKA5; -.
DR SMR; A0A1U7WKA5; -.
DR STRING; 4096.A0A1U7WKA5; -.
DR GeneID; 104229443; -.
DR KEGG; nsy:104229443; -.
DR eggNOG; KOG1176; Eukaryota.
DR OrthoDB; 2596785at2759; -.
DR UniPathway; UPA00372; UER00547.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd12118; ttLC_FACS_AEE21_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43859:SF24; 4-COUMARATE--COA LIGASE; 1.
DR PANTHER; PTHR43859; ACYL-ACTIVATING ENZYME; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 65..450
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 500..575
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 592 AA; 65784 MW; A44FF29EFFE8641A CRC64;
MSHSGILARN LIYSTNSVQI QHTNTQRPRH LCQLSMNLQS EPLRSMDGLL KCSANYVPLT
PISFLERAAN VFRGRTSIID GPSVKYTWEE THARCIKLAS ALSELGICRG DVVATVARNV
YAMQELHFAV PMAGAVLCTL NTRHDSAMIS VLLKHSEAKV IFVDQHLLQL AQGAIDILAN
EKVIPPRVVV ISESNNSTPT GANSNTHEYE SLLESGNTEF AVRWPISEFD PISVNYTSGT
TSRPKGVVYN HRGAYLNTIA TFMLHEMSSW PVYLWTVPTF HCNGWCLTWG LAALGGTSIC
LRQVSPKVIF ESIVEHNVTH LSGAPTILNM IVNSPESDRK PLPHKVNIMT GGSPPPPQIL
SQMEELGFRV HHLYGLTETY GPGTYCLWKP EWDSLPPNEK YKLKARQGVQ HLCSESVDIM
DPTTMKKVPE DGKTIGEIVF RGNTVMSGYL KDVEATEEAF KGGWFHSGDL AVKHPDGYIE
VKDRLKDIVI SGGENISTVE VERVLYSHPA VLETAVVARP DNYWGQTPCA FVKLKDGFNN
ITDQEIINFC RDNLPHYMAP RTVIFQDLPK TSTGKIQKFI LRDKAKALGS LF
//