ID A0A1U7WMX9_NICSY Unreviewed; 984 AA.
AC A0A1U7WMX9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nardilysin isoform X2 {ECO:0000313|RefSeq:XP_009779933.1};
GN Name=LOC104229059 {ECO:0000313|RefSeq:XP_009779933.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009779933.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009779933.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009779933.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR RefSeq; XP_009779933.1; XM_009781631.1.
DR AlphaFoldDB; A0A1U7WMX9; -.
DR GeneID; 104229059; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 103..229
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 258..439
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 445..728
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 733..919
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..90
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 113373 MW; 6329336BDAD3DF79 CRC64;
MAVGGGRTLT ADDLVEKSPH DKRLYRYMQL PNGLCALLVH DPDIYPDGLP EHSENENNES
EEDEGSEDED EEETEDSDFD EEESDGADEE DSEVKDKGSK GASQKKAAAA MCVRMGSFVD
PYDAQGLAHF LEHMLFMGST EFPDENEYDS YLSKRGGCSN AYTETEHTCY HFEVKRDCLK
GALRRFSQFF VSPLVKAEAM EREVQAVDSE FNQVLQNDSC RLQQLQCHTS TPGHPFNRFF
WGNKKSLADA VERGVNLREQ ILKLYHDNYH GGSMKLVIIG GESLDILESW VLELFSSVKK
GPLVNPDGRT ELPIWRVGKL YWLEAVKDVH ILDLSWTLRS LRKGYLKKAE DYLAHLLGHE
GKGSLLFSLK ARGLVTSISA GVGDEGMHCS SFAYIFGMSI HLTDSGLEKI FEIIGFVYQY
LKLLRQNSPQ EWIFKELQDT ANVEFRYAEE QPQDDYAAEL AEGLLVYPPK HVIYGDYAYD
LWDPEFIKYV LDFFRPENMR VDIVTKSFQK SDDVQQEPWF GSRYVEEDIP SSLFELWKDP
DEISVCLHLP AKNEFIPSDF SIRAEKANCD SKNAKPRCIL EEPLMKIWYK LDKTFKLPRA
NTYFRITLRG GYGNLKNALL TELFIHLLKD ELNEIIYQAS VAKLETSVSL YGDKLELKVY
GFSDKLPVLL SKVLAMTKSF LPRDDRFMVI KEDMERTLKN TNMKPLNHSS YLRLQVLCQS
FWNVEEKLLL LNDLTLAELK AFIPELLSQL YIEGLCHGNL LEEEALNISN IFRSNFSAQP
LPSEMRHKEY VMCLPAAADL VRDIRVKNKL ETNSVVELYF QIEPEEDTSL IKLKAVTDLF
DEFVEEPLFN QLRTKEQLGY VVDCSARVTY RIMGFCFRVQ SSDYDPVYLQ GRIDNFIDGV
KELLDDLDDK SFESYRSGLI AKLLEKDPSL AYETNRLWGQ ITDKRITEQI WRIFINLKGI
MWVMPRGILD VLRCWSQWRS QEIQ
//