ID A0A1U7WSP2_NICSY Unreviewed; 1796 AA.
AC A0A1U7WSP2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Eukaryotic translation initiation factor 4G isoform X2 {ECO:0000313|RefSeq:XP_009782952.1};
GN Name=LOC104231628 {ECO:0000313|RefSeq:XP_009782952.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009782952.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009782952.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009782952.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_009782952.1; XM_009784650.1.
DR GeneID; 104231628; -.
DR OrthoDB; 1123866at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.180; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF9; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|RefSeq:XP_009782952.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 1608..1732
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1796 AA; 194211 MW; 29CCA0899FF2E8FA CRC64;
MSHNQSRADT RESSQYRRTG RSGSFNQHRG GNKGSGGGGG GSGAAPPVSS TTNPSLSSNR
SFNKKYNNAQ GGQHRVSGAS AGSDSHQNGA HHQQQQALHG ASDVPVTSAN APVPGAPVKQ
TDASTQKITR AVPRAPTSNV AASTSESTAP VTPAKTSGDA SRSFPLQFGS ISPGVMNVLQ
IPARTSSAPP NLDEQKRAQA RSDTSKAIPS LPTPSTSNQP MPRKDAGPRN QSNPGESHGV
AAKPKRDVQV SAPPSVTQTQ KPSAHPMPGM HMQIPFHKPP QVPVQFGGPG PQIPSHSMSA
TSLPMPMHLP IGTPPMQQPM FVSGLQPHPM QSQGMMHQGQ GLNFSSGMGP QLPPQLGNMG
MNMPSQFPQQ QAGKYLGARK TVKITHPETH EELRLDGTPG SRSHPNMPPQ SQPIASFPPG
HPINYYPNSY NSSSVYFQAP SSLPLNNPQS SQPPRLFSQV TVKPAAGTHP EKEQLPSVSS
AAFGKDQVRL SKPPGGDSAH PQKDMDTIHQ SSSTQSKIGN ASKSASRPVA NIQSIKVADS
ISEQSPAAGV SSLTSQAPSE PSVSVITDSS VDATTETLGG LEPIEDQQKK QVIRGQALGK
STSVSSPPSQ YPLTGPVEVK TAASLGTAAV GNSRENLSPS ESVELKTCIT GDSGKEVSPE
LLDSRNLDAG KPVPKTGDRY EVTLPEVGEQ GENNISKPSS GSLLVKSVEV SGLTEEGSLE
KATNANVESR KPETGEEDTN ASAGSTGVDS MADSIKSFTC NQNFTDTEAC TSAIGLSAHD
DQASDIADPE EAAVTESAVV SQECASNLVK NSDEATSKCE DENTETETDN TGVAKSSSSV
KEKSLVDFNV PKVTAARGKK KMKDLYKKAD AAGATSDLYM AYKGPEKKDE LAPSVEAGEI
TSKNNSKPLS DDAPQEDLTS TKKVGEVKAE PDDWEDAADI STPKLEAAPE HGKQVDGEDG
DGMTTKKYSR DFLLKFAEQC IDIPEGFQVP SDIADILINA NISVSREPCP SPGRALDRPS
SGHRERRGGG IGDGDKWSKV PGPLMPGRDI QPDLVYGGNV MGFRPGPGGN YGVLRHPRAP
MPIQYAGGIL SGPMQSMGPH GGVQRNGVDA DRWQRGTAFQ KGLMPSPQTP AQIMHKAERK
YEVGKITDEE QAKQRQLKAI LNKLTPQNFE KLFQQVQEVN IDNVVTLNGV ISQIFDKALM
EPTFCEMYAN FCQHLAAELP DLSVDNEKIT FKRLLLNKCQ EEFERGEREE QEANVTNEEG
EVKLSAEERE EKRVKARRRM LGNIRLIGEL YKKRMLTERI MHECIKKLLG DYHNPDEENI
EALCKLMSTI GEMIDHAKAK EHMDAYFDMM EKLSNNMKLS SRVRFMLKDS IDLRKNKWQQ
RRKVEGPKKI EEVHRDAAQE RHAQTTRLAR TPSLGGSTRR GQPMDFAPRG SMLSSPGSQM
GGFRPMSPQV RGFGMQDVRV DERHSFDNRT LSLPLTQRPL GDDPITLGPQ GGLAKGMSSR
GQPAAPSIPF TDNVPNFGDS RRMVHAQNGY GSLPERAPYA SREELTPKYM PDRFYSQHDQ
ASAPERNLTY GSRDRGFDTS RPASPPVRSG GPTSTQNVPS EKIWSEERLR DLSMAAIKEF
YSAKDEKEVA LCVKDLNAPN FYPSMISIWV TDSFERKDME RDHLAKLLIS LAKSQDVTIS
QDQLVKGFES VLVTLEDAVN DAPRAAEFLG RIFAKVILEN VLPFNEIGHL IYKGGEEEGR
LVEIGLAAEV LGSALEVIKL EKGESVVLEI CRSSTMRLEN FRPPGSNKQL KLDKFI
//
