ID A0A1U7WUB3_NICSY Unreviewed; 493 AA.
AC A0A1U7WUB3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN Name=LOC104227687 {ECO:0000313|RefSeq:XP_009778286.1,
GN ECO:0000313|RefSeq:XP_009778287.1, ECO:0000313|RefSeq:XP_009778288.1,
GN ECO:0000313|RefSeq:XP_009778289.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009778289.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009778286.1, ECO:0000313|RefSeq:XP_009778287.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009778286.1,
RC ECO:0000313|RefSeq:XP_009778287.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR RefSeq; XP_009778286.1; XM_009779984.1.
DR RefSeq; XP_009778287.1; XM_009779985.1.
DR RefSeq; XP_009778288.1; XM_009779986.1.
DR RefSeq; XP_009778289.1; XM_009779987.1.
DR STRING; 4096.A0A1U7WUB3; -.
DR GeneID; 104227687; -.
DR KEGG; nsy:104227687; -.
DR eggNOG; KOG1317; Eukaryota.
DR OrthoDB; 1341425at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 43..371
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 437..489
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 493 AA; 53441 MW; ACB11AEEFCEFCCA9 CRC64;
MAMLIAARRL SAGSALSDSL RYTSCWRFFS TSFREEKDTF GPILVPSDKL WGAQTQRSLQ
NFDIGGERER MPEPIIRAFG ILKKCAAKVN MEYGLDRSIG KAIMQAAEEV AEGKLNDHFP
LVVWQTGSGT QSNMNANEVI ANRAAEILGH KRGDKHVHPN DHVNRSQSSN DTFPTVMHIA
AAMELNKRLV PNLKQLHTSL HSKSVEFKDI IKIGRTHTQD ATPLTLGQEF SGYATQVKYG
IDRVLCTLPH MYQLAQGGTA VGTGLNTKKG FDIKIAAAVA EETNLPFVTA ENKFEALAAH
DAFVETSGAI NTVAASLMKV GNDIRFLGSG PRCGLGELIL PENEPGSSIM PGKVNPTQCE
ALTMVCAQVM GNHVAVTIGG SNGHFELNVF KPMIANALLH SVRLIGDASA SFEKNCVRGI
QANRERIAKL LHESLMLVTC LNPKIGYDNA AAVAKKAHKE GTSLKDAALN LGVLKSEEFD
QLVVPEKMIG PTD
//
