ID A0A1U7WYL7_NICSY Unreviewed; 340 AA.
AC A0A1U7WYL7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Thermospermine synthase ACAULIS5-like {ECO:0000313|RefSeq:XP_009785002.1};
GN Name=LOC104233312 {ECO:0000313|RefSeq:XP_009785002.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009785002.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009785002.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009785002.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
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DR RefSeq; XP_009785002.1; XM_009786700.1.
DR AlphaFoldDB; A0A1U7WYL7; -.
DR SMR; A0A1U7WYL7; -.
DR STRING; 4096.A0A1U7WYL7; -.
DR GeneID; 104233312; -.
DR KEGG; nsy:104233312; -.
DR eggNOG; KOG1562; Eukaryota.
DR OrthoDB; 867at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0010487; F:thermospermine synthase activity; IEA:UniProt.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR PANTHER; PTHR43317:SF1; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 35..272
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 188
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 340 AA; 38495 MW; C0800A9FBD5C4D9E CRC64;
MGSEALEFFA CDNTFRYEPK RITMEESDDL PINDGSWFEE EIDVDLKWSF ALNSVLHKGT
SEYQDIALLD TKHFGKVLVI DGKMQSAEVD EFIYHECLIH PALLCHPNPK NVFIMGGGEG
SAAREALRHK SMEKVVMCDI DQEVVDFCRK HLTANHEAFR NKKLNLIIND AKAELEQRQE
KFDIIVGDLA DPVEGGPCYQ LYTKSFYENI LKPKLNDSGI FVTQAGPAGV FTHKEVFSSI
YNTIKQVFKY VLAYTAHVPS FADTWGWVMA SDQPFCLDAG KLDKKIAERI EGELLYLNGA
SFFSSTILNK TVAKTLKNET HVYTEDDARF IHGHGVAFRN
//
