ID A0A1U7X3I6_NICSY Unreviewed; 603 AA.
AC A0A1U7X3I6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Flap endonuclease GEN-like 1 isoform X2 {ECO:0000313|RefSeq:XP_009781434.1};
GN Name=LOC104230353 {ECO:0000313|RefSeq:XP_009781434.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009781434.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009781434.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009781434.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_009781434.1; XM_009783132.1.
DR AlphaFoldDB; A0A1U7X3I6; -.
DR GeneID; 104230353; -.
DR OrthoDB; 26655at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF59; FLAP ENDONUCLEASE GEN-LIKE 1; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|RefSeq:XP_009781434.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 1..97
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 129..199
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 525..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 68419 MW; 57C215535E13E180 CRC64;
MGVVGNFWEL LKPYGRAEGF DFLRNKRVAV DLSYWIVQQE TAVLKAHIRN PHIRLTFFRT
INLFSKFGAF PVFVADGTAS PLKSQARIAR FFRASGIKLS SLPAAEEGIS IERNKAFQKC
EQECVELLEL LGVPVLKAKG EAEALCAQLN QEGQVDACIT ADSDAFLFGA KCVIKNIQPN
SKEPLEFYHM SDIESGLGLR RNHLIAISLL VGNDHNLIGV PGIGLETALR FVKSFSEDEI
LSRLQEIGRG DVQVLQRDVN LDCNYIPGSD ESPWKTKVQH CSFCGHPGSK KAHHKFACQD
CSSTANEGCI QKPSGFKCNC SSCDLDNKEK EQKRNENWQI KVCRMIASEQ NFPNNEITEM
YLNKHQQSDG DYHLTWSSPK TDMLVDYLAY YQHWEPSYTR QRMLPMLSTI FLRDVASNSK
DQLLCGQYEF DSIQRVKTRF GHQLYVINWK KTTREMSNEI CIPSENPDME QELRIADDGS
KDLLDEPEVL QIHIKDGCSF LSTEEDMELV QSAFPEKVSQ FLRDKELKET KSSRKRSVKP
ENSESPRGVQ LSITNFYRSS KVQATPGENE SRSSKISADT SGERDKEPIR NYSKSARRKL
LFG
//
