ID A0A1U7X5Y8_NICSY Unreviewed; 302 AA.
AC A0A1U7X5Y8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Probable 3-hydroxyisobutyrate dehydrogenase-like 2, mitochondrial {ECO:0000313|RefSeq:XP_009785096.1};
GN Name=LOC104233403 {ECO:0000313|RefSeq:XP_009785096.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009785096.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009785096.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009785096.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_009785096.1; XM_009786794.1.
DR AlphaFoldDB; A0A1U7X5Y8; -.
DR SMR; A0A1U7X5Y8; -.
DR STRING; 4096.A0A1U7X5Y8; -.
DR GeneID; 104233403; -.
DR KEGG; nsy:104233403; -.
DR eggNOG; KOG0409; Eukaryota.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF13; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 2, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 14..169
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 173..295
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 179
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 302 AA; 31589 MW; BE9469C786E84817 CRC64;
MTSYPAPINP TQTRIGWIGT GVMGAAMASR LLSAGYSVTI YARNPSKVVH LQSQGAHLAD
SPADLARNSE VIFTMLGHPS DVRQIVLEGL ISSVNPNCVI IDHTSSHPVL AKQIFDAARE
KNCWAVDAPV SGGDIGARKG KLAIFAGGNE DVVKWLKPLF DVLGKVTFVG GPGKGQSCKI
ANQIVVGGNL LGLSEGLVFA DKAGLDKMKF VEAIKGGAAG SKVMELFGVR MIGRDFRPGG
FTEYMVKDLG MGLDVGAEQG DDVVVLPGAA LSKQLFSAMV ANGDGKLGTQ GLITVIERIN
GK
//
