ID A0A1U7X7H6_NICSY Unreviewed; 687 AA.
AC A0A1U7X7H6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC104231184 {ECO:0000313|RefSeq:XP_009782435.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009782435.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009782435.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009782435.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000256|ARBA:ARBA00003861}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_009782435.1; XM_009784133.1.
DR AlphaFoldDB; A0A1U7X7H6; -.
DR GeneID; 104231184; -.
DR OrthoDB; 1211501at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR PANTHER; PTHR45647:SF56; U-BOX DOMAIN-CONTAINING PROTEIN 50-RELATED; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 344..687
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 611..685
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT COILED 215..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 278..312
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 687 AA; 78363 MW; 62A49DF71FADE637 CRC64;
MVDLITSLRI TKLVMSLTFM KSSSWKSRSA ISGSFFVHRQ KPEFCELFII CGGKLVFLRE
GNNEGLIEDD QGEMVANSRS KRQSFRDLVV KMFPENSAKM KNQCDSSASN GSFDQWEKYK
EEIENYMSQI LSSNAEEIDD FVANESLQKS NTELVMADNM TVQEKRKALK IKFLEIKQTI
QLSREEAKGH VRGHAKAQWA TTLCTRRAEE IDGCINDEIA RKADLKRELD ATKEELSELH
TEVEITTSRL NSILELQREL SNKLQLSSVA RSRAEVKVEK VVKQRTDTLQ EIDEYRKQRD
VLRRRIEFCR EKDAIGNATM LMKPSFEYKE FTAAEIRAAT DGFSDRMRLK SGGDWTDVYK
ARLNHTSVAI KLYSSGDVDS ADAFRAKVKL FSHMRHPHIL AMIGFCSELR CIVFEYMHNG
CLRDILFSGK RSSKRRNKCL NWKARICIAA DVCTGLCFVH RAKPRPVAHG NLNPSKILLD
RNNVAKIHGF KTPLSSDKLD IRSDIRAYGN LVLQILTGRN WAGLVEEAIM MDQTKLIEVL
DPMAGEWPLD IAVELGRIGI KCLSIHEDKE LNMTSLAREV EKVKKLADEI VANGECVVAN
ERNQDDEDSA EFPNFFLCPI LQEVMKNPHV AADGFSYELE AIEEWLKTGR DTSPMTNLRL
DDKILTPNHS LRSLIEDLQK KRSISTR
//
