ID A0A1U7XDJ4_NICSY Unreviewed; 878 AA.
AC A0A1U7XDJ4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=E3 SUMO-protein ligase SIZ1 isoform X1 {ECO:0000313|RefSeq:XP_009787726.1, ECO:0000313|RefSeq:XP_009787727.1};
GN Name=LOC104235619 {ECO:0000313|RefSeq:XP_009787726.1,
GN ECO:0000313|RefSeq:XP_009787727.1, ECO:0000313|RefSeq:XP_009787728.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009787726.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009787726.1, ECO:0000313|RefSeq:XP_009787727.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009787726.1,
RC ECO:0000313|RefSeq:XP_009787727.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the PIAS family.
CC {ECO:0000256|ARBA:ARBA00005383}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_009787726.1; XM_009789424.1.
DR RefSeq; XP_009787727.1; XM_009789425.1.
DR RefSeq; XP_009787728.1; XM_009789426.1.
DR STRING; 4096.A0A1U7XDJ4; -.
DR GeneID; 104235619; -.
DR KEGG; nsy:104235619; -.
DR eggNOG; KOG2169; Eukaryota.
DR OrthoDB; 921278at2759; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0019789; F:SUMO transferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR CDD; cd15570; PHD_Bye1p_SIZ1_like; 1.
DR CDD; cd16792; SP-RING_Siz-like; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR031141; SIZ1/2_SP-RING.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10782:SF93; E3 SUMO-PROTEIN LIGASE SIZ1-LIKE; 1.
DR PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|RefSeq:XP_009787726.1,
KW ECO:0000313|RefSeq:XP_009787727.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00452}.
FT DOMAIN 11..45
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 347..430
FT /note="SP-RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51044"
FT REGION 536..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 95520 MW; 73862D0A7852D4F5 CRC64;
MDLVASCKDK LAYFRIKELK DVLTQLGLSK QGKKQDLVDR ILATLSDERV SGMWPKKNSV
GKEDVAKLVD DIYRKMQVGG ATELASKSQV VSDSSNVKLK EEIEDSSYHM KIRCVCASSL
QTETMIQCED RRCHTWQHVR CVIIPDKPME GGDPPIPPTT FYCELCRLGR ADPFWVTMGH
PLYPAKLSIT SVPADGTNPV QSIEKTFQIT RADRDLLAKQ EYDLQAWCML LNDKVQFRMQ
WPQYADLQVN GVPVRAINRP GSQLLGANGR DDGPIITPCT RDGINKITLT GCDARVFCLG
VRLVKRRTVQ QVLSLIPKES DGEQFEDALT RVRRCVGGGT ATENADSDSD LEVVADCIPV
NLRCPMSGSR MKVAGRFKPC IHMGCFDLEV FVEMNQRSRK WQCPICLKNY ALEHVIIDPY
FNRITSQLRS CGEDVAEIEV KPDGSWRAKI EGDRRSLGDL GCWHLPDGSL SESLDIESKP
KPEILKQIKQ EGGSDGNGLK VGLRKNINGL WEISKPEDQT FSSGSRLRDN FGQDIIPMSS
GATGSGKEGE DASVNQDGNG NLDFSNNAFD LEAISLIDPT YGFGNGNPSV PAGDAEVIVL
SDSEEENEPI ISSGPIFNNN HNDAPVVPFP GQSQGIPDAF HDSTLVNSGN SCLGLFNSND
DEFGMNMWSL PSGTQGGPGF QLFSSDADVS GSLVDVQHGS INCPSSLGGY GLAADTGIGS
TSLLPETYAN RPNANINDSL VDNPLAFSGN DPSLQIFLPT RPSDTSVEAT RDQPDVSNGV
GTEDWISLRL GGDGGVHGDS VANGLSSGQQ VQTKDTALDS LADTGSDATV CAASLLLGMN
DSRPTKSSRE RSDSPFTFPR QRRSVRPRLY LSIDSDSE
//
