ID A0A1U7XFY8_NICSY Unreviewed; 5101 AA.
AC A0A1U7XFY8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Auxin transport protein BIG isoform X2 {ECO:0000313|RefSeq:XP_009785859.1};
GN Name=LOC104234061 {ECO:0000313|RefSeq:XP_009785859.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009785859.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009785859.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009785859.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_009785859.1; XM_009787557.1.
DR GeneID; 104234061; -.
DR OrthoDB; 10597at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19681; UBR-box_BIG_like; 1.
DR CDD; cd02249; ZZ; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR003126; Znf_UBR.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1558..1629
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 2598..2657
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT ZN_FING 1558..1629
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1522..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3805..3853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4947..4973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1545
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3816..3853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4958..4973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5101 AA; 564451 MW; 922944A63D4205AA CRC64;
MAEIAKLVDV FSSGDDLSQR LRADSSLNLG FRKLCSILRQ AVEPVAGDGN KLGLQFWDQS
QIQAVTSLAL ALVNSTRSLS VERVEPVIVA AIQLSVEFAL CYLEKWICNS DDSMLQSYIL
QLLEIALVDE TDKELDLLQP CSSNASMDML PIAVIEDNCS KWQGGTRCML QGGRCSKEEK
AADSLLMTLA SEWMHPDNVN TTTLRQSVPY DCNKLINVSQ HWAVVHLECV HRLVTICKDL
LRLPAPSDEK SAIPNLKKRF SFCVKVFKLL GSLTKNSSYT HFDAKLFRSV ASFTEVLPTL
FKLPFDFVSG YPAVESGLDS QVMLLLEEFI QIVQTIFCNT NVFQNIQACI AALILDHLDP
DVWKYSSAVN PRPPLAYCPR VVVYVLKLIL DVRNRTYQLF EYKGLDVEGV STSQLLEPPL
CQVHSAKVNL LKKYSVEELL RIIFSPSVQW VDNVMQLLLF LHSEGVKLKP KLERSCSSVT
KTSVTSESEN TACHEDEALF GDLFSEGGRS AGSVDGYDQP AVAHSSNTSS TPIQAATELL
SFLNDCILSP EWCGPVYEDG CRKFTSYHID ILLSVLSSEG CDAEATGHDA GIALNEQMKL
GYRHLSEICL DLFHNLLSRH ALSDRVEETL VEKILVIENG AFLYNDLTLG LLAHAVVCLV
DSAGSSLRTK MYNIFADFVC EKAKTICSKC PNLDELLGIL PSLFHVEILL MAFHLSSEDE
KAVQANVVFS ALKAVAVPSA GFDSTQLSCW ALLVSRLIVM LRHMLFYPLV CPSSLLLEFR
TKLREASSSR LRPRVSGSRA SSWVSILFEG VMGGFIKETP TCNALLSHLI DITPLPPSAC
RDDPTIECLG LSWNDICASF SRILRFWEGK KPEKVEDLIL ERYIFVLCWD LPVVKSTSEH
LHRWLTSAEV PELSNAEHFV YFSQLFSGDM GKINYSHLSV MLMDLIHRLH DLHVSEDVGE
FGWDFLRAGS WLSLSLSLVT AGTAGHCMDK ALASAVPMLP EQTSRDGKFY AFTEGVISTL
VGTNQVERLI RVLSSLLKRY LQVYQKALIM TIDGDQFSPN RLSPAMSFVH AGFDKCKQDE
LLEKMGSDPC QYKPLYGTLS RLDTALDKLS LGSHSKILWE SLLHGFPCLL QPPSGTLLSS
ILNVAGVVNC IDGLMKVIDA GGVLYLETQA ISQILELVCR IKCDSIFEDL HGKCNAIYQR
LTEGSGGVDY SSLFVLKHME EFLRCVNERD GGDTSGIYEA LIVKVIDIVD SLKREPSGTG
VLKYFLSLED GSKQIKDLYG SQRGDLLVLV DALDGCNSEQ VSIRVLNFFV DLLSGDMYAH
VKEKLQKKFL HMDMVYLSKW LETRLLGSVT EESSGVACAT GASVSLREST MNFITCLLSP
SSGILSQELH KHLVKSMLIS LDKAFLLFEF TVAKCYFNFL VQLSGGENLI KQLMRQTMLL
TEKLADDENL LQGLKYLFGF FASVLSDCCS AKSATERSLV KSIPSSSSAV GSAPTRSICS
RKNADAVVLS SSQGASAIEC DATSVDEDED DGTSDGENGS LDKDEEEDNN SERALASKVC
TFTSSGSNFM EQHWYFCYTC DLTVSKGCCS VCAKVCHRGH RVVYSRSSRF FCDCGAGGVR
GSNCQCLKPR KFAGSNNAAS RGASNFQSFL PFTENGDQLP DSDSDIDEDV LVEADNSIKM
SIPKDLQDGM PILLDELDLE SCVVRLCSSL LPSITSRRDS SLSRERKIFL GNEKVLCNSV
DLLQLKKAYK SGSLDLKIKA DYSNAKELKS HLASGSLVKS LLSVSTRGRL AVGEGDKVAI
FDVGQLIGQA TVAPVTADKT NVKPLSKNVV RFEIVNLIFN PLVENYLAVA GYEDCQVLTV
NHRGEVSDRL AIELALQGAY IKHVDWVPGS QVQLMVVTNK FVKIYDLSLD NISPVHYFTL
PDGMIMDAAL IVASQGRMFL IVLSEHGSLY RLELSTKGNV GAKPLKEIMQ IEGKERHAKG
SSLYFSSMHR LLFLSLQDGT TLVGRVNPDA TSLTEVSAIL ENETDSKHRP AGLHRWRDLF
GGSALFVSFS SLNSNAACAV SFGEHQVLVQ NLRHSVGSAS PVVGVATYKP LSKDKIHCLV
LHEDGSLQIY SHVPAGVDSG VSAISDKVKK LGPGILNNKA YGGAKPEFPL DFFEKTVCIT
QDVKLSSDAI RNGDSELAKQ TLASEDGFLE SPNPGGFKIT VSNSNPDLVM VGLRLHVGNT
SANHIPSEIT VFQRVIKLDE GMRSWYDIAF TVAESLLADE EFTVSVGPTF SGAALPRIDS
LEIYGRAKDE FGWKEKMDAV LDMEARVLGC NSWPAGSRRK CRATQSAPLQ ELVVAAGLKL
LSRIYSLCKP KGCSKVEEAK VELSKLRCKP LLEVIFESDR EPLLQAAANR VLQAVFPKRE
IYYQVKDAMR LAGVVKSTAM LSSKLGVDGT AAGWIIEEFT AQMRVVSKIA LHRRSNLASF
LEMNGSEVVD GLMHVLWGIL DIEQPDTQTM NNIVVSSVEL IYCYAECLAL HGKDGGRSSV
APAVSLFKKL LFSTNEAVQT SSSLAISSRF LQVPFPKQTM IGTDDVENPS CVPTRVDASA
GASGSTQVMV EEDSITSSVQ YCCDGCSTVP ILRRRWHCTV CPDFDLCEAC YEVLDADRLA
PPHSRDHPMT AIPIEVETFG GEGSEIHFST DDLSDPGLLT VASDVGVQNS APSIHELEPN
ESEEFSPSIL DPVTISASKR AVNSLLLSEL LEQLKGWMET TSGTGAIPVM QLFYRLSSAV
GGPFADSSEP ESIGLENLIK WFLDEINLNK PFVARSRTPF GEVTILVLMF FTLMLRNWHQ
PGTDGSATKS GGVTEAHDKA ALHISPSTCV AASPTLDGQE KIDFISHLLR ACSYLRQQAF
VNYLMNILQE LTQVFKSPPI STDASSGLNT ASGCGALLTI RREVPAGNFS PFFSDSYAKS
HRADIFVDYH RLLLENTFRL LYSLIRPEKH DKAGEKEKIH KMISGKDLKL DGYQDVLCSY
INNPNTSYVR RYARRLFLHL CGSKTHYYSV RDSWQFSTEV KKLYKHINKS GGFQSSISYE
RSVKIVRCLT TMAEVAAARP RNWQKYCLRH GDLLPFLLNG IFYFGEECVI QALKLLNLAF
YTGKDSTHSS QKAEVAEAGT TVSKLGSQAP EYKKKKKGED SESGVEKTQL DMEAVVDVFI
GKGGDVLKQF IDCFLLEWNS SSVRSESKSV LLGVWHHGNP VFRETLLTAL LEKVKSLPMY
GQNIIEYTEL VTFLLGKVPD HGAKLQSAEV VDKCLTADVI NCIFETLHSQ NELLANHPNS
RIYNTLSGLV EFDGYYLESE PCVACSSPEV PYSRMKLESL KSETKFTDNR IIVKCTGSYT
IQSVAMNVHD ARKSKSVKVL NLYYNNRPVA DLSELKNNWS LWKRAKSCHL AFNQTELKVD
FAIPITACNF MIELDSFYEN LQALSLEPLQ CPRCSRAVTD KHGICSNCHE NAYQCRQCRN
INYENLDSFL CNECGYSKYG RFEFNFMAKP SFTFDSMENE EDMKRGLTAI EAESENAHRR
YQQLLGFKKP LLKIVSSVGE NEMDSQQKDS VQQMMVSLPG PSCKINRKIA LLGVLYGEKC
KAAFDSVSKS VQTLQGLRRV LMNYLHQKQS DNVGPASRFV VSRVPNSCYG CASTFVTQCL
EILQVLSKNP ASKKQLVAAG VLSELFENNI HQGPKTARVQ ARGALCAFSE GDTNAVAELN
SLIHKKVMYC LEHHRSMDIA LATREELSLL SDVCSLSDEF WESRLRVVFQ LLFASIKVGA
KHPAISEHVI LPCLRIISQA CTPPKPDGVD KEQGAGKSSH VTQVKDDSSN VSGSNSLVSG
SKSMSESSEK SWNGSQKAQD IQLLSYSEWE KGASYLDFVR RQYKVSQAGK SGQRSRLQRQ
DYLALKYLLK WKRRVSKTAR NEISSFELGS WVTELILSAC SQSIRSEMCM LISLLCGQSS
SRQFRLLNLL MSLLSATLAA GENAAEYFEL LFKMIDTEDA RLFLTVRSCL TTICKLITQE
LVNVEKLERS LHVDISQGFI LHKLIELLGK FLEVPSIRSR FMREHLLSEV LEALIVIRGL
VVQKTKLIND CNRLLKDLLD SLLLESNENK RQFIQACISG LQIHGDENRG RTSLFILEQL
CNLISPSKPE PVYLLILNKA HTQEEFIRGS MTKNPYSSAE IGPLMRDVKN KICQQLDLLG
LIEDDYGMEL LVAGNIISLD LSIAQVFEQV WKKSSSQSAS VVAAATSLSS SAAVSGRDCP
PMTVTYRLQG LDGEATEPMI KEIDEDREET QDPEVEFAIA GAVRECGGLE ILLGMVQRLQ
DDFKSNQEQL VAVLNLLMLC CKIRENRKAL LKLGALGLLL ETARRAFFVD AMEPAEGILL
IVESLTLEAN ESDNISITPG VNVVSSDEAG AGEQAKKIVL LFLERLSHPS GLKKSNKQQR
NTEMVARILP YLTYGEPAAM EALVQHFEPC LQNWCEFDRL QKLYEDNMKD ETIAQQASKQ
KYTLENFVRV SESLKTSSCG ERLKDIILEK GITGAAVSHL KECFAFTGQA GFKSTVEWAS
GLKLPSIPLI LSMLRGLSMG HLATQKCIDE GGILPLLHAL EGVSGENEIG ARAENLLDTL
SDKEGKGDGF LAEKVHQLRH ATRDEMRRRA LRKRTELLQG LGMRQELSPD GGERIVVARP
VLKGLEDVED EDEEGLACMV CREGYRLRPT DLLGVYTYSK RVNLGIGSSG NARGDCVYTT
VSHFNIIHFQ CHQEAKRADA ALKNPKKEWD GAALRNNETL CNNLFPVRGP SVPMGQYIRY
VDQYWDYLNA LGRADGSRLR LLTYDIVLML ARFATGASFS ADCRGGGKES NARFLPFMMQ
MARHLLDHDS SQRHIMIKSI STYLSSPASE SRASTTAGTQ TSAGTEETVQ FMMVTSLLSE
SYESWLQHRS SFLQRGIYHA YIQRTHGRPV PRSSRNLSGA LKPESGSTSA SASEAGGSVE
LFSTIHPMLV YTGLIEQMQR FFKVKKLSSV TILRTQGTSK NVEEDDESRK LEGWEVVMKD
RFLNVKEMAD FSSKLLSWLD GMTSATNFQE AFDILGVLGD VLSGFSRCED YVHAAISGGK
N
//
