ID   A0A1U7XG43_NICSY        Unreviewed;       275 AA.
AC   A0A1U7XG43;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Aquaporin NIP1-1 {ECO:0000313|EMBL:DAC84347.1, ECO:0000313|RefSeq:XP_009785425.1};
GN   Name=LOC104233688 {ECO:0000313|RefSeq:XP_009785425.1};
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009785425.1};
RN   [1] {ECO:0000313|Proteomes:UP000189701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA   Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA   Peitsch M.C., Ivanov N.V.;
RT   "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT   tomentosiformis.";
RL   Genome Biol. 14:R60.1-R60.17(2013).
RN   [2] {ECO:0000313|EMBL:DAC84347.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=32517797;
RA   De Rosa A., Watson-Lazowski A., Evans J.R., Groszmann M.;
RT   "Genome-wide identification and characterisation of Aquaporins in Nicotiana
RT   tabacum and their relationships with other Solanaceae species.";
RL   BMC Plant Biol. 20:0-266(2020).
RN   [3] {ECO:0000313|RefSeq:XP_009785425.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_009785425.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|RuleBase:RU000477}.
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DR   EMBL; BK011452; DAC84347.1; -; mRNA.
DR   RefSeq; XP_009785425.1; XM_009787123.1.
DR   STRING; 4096.A0A1U7XG43; -.
DR   GeneID; 104233688; -.
DR   KEGG; nsy:104233688; -.
DR   eggNOG; KOG0223; Eukaryota.
DR   OrthoDB; 5490746at2759; -.
DR   Proteomes; UP000189701; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   NCBIfam; TIGR00861; MIP; 1.
DR   PANTHER; PTHR45724:SF40; AQUAPORIN NIP1.1; 1.
DR   PANTHER; PTHR45724; AQUAPORIN NIP2-1; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; Aquaporin-like; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000477};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   275 AA;  29279 MW;  E87CCD6C7AA3DF22 CRC64;
     MADQIAAGAN GNHVVTLNIK EDDDLNNNDS SSSCSFLTVP FIQKVIAEMI GTYFLIFAGC
     GSVVVNSDKG MVTFPGIAIT WGLVVMVMVY SVGHISGAHF NPSVTIAFAT VKRFPWKQVP
     AYVAAQVLGA TLASGTLRLI FNGKHDHFAG TLPTGTEFQS FVVEFIITFY LMFVISGVAT
     DNRAIGELAG LAVGATILLN VMFAGPISGA SMNPARSLGP AIVSTHYRGL WIYLVSPTLG
     AIAGAWVYNI IRFTDKPLRE ITKSGSFLKS KNSST
//