ID A0A1U7XR71_NICSY Unreviewed; 1093 AA.
AC A0A1U7XR71;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC104241319 {ECO:0000313|RefSeq:XP_009794567.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009794567.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009794567.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009794567.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_009794567.1; XM_009796265.1.
DR AlphaFoldDB; A0A1U7XR71; -.
DR GeneID; 104241319; -.
DR OrthoDB; 1055564at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF436; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..117
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1093 AA; 123737 MW; 46DE14BB9F2E1400 CRC64;
MRAIEESRIA LIIFSRNYAN SIWCLDELVK IMECKNLNGQ IVFPVFYDVD PSTVRKQKSS
FGEAFSSHEA HGCFKLQKWR AALEEAANLS GCDLPNTANA HEAKVIKQIV EDILAKLGGQ
RHAINAENLV GMESQMQKVY KMLGIGFGGV HFVGIFGMSG VGKTTLARVI YDNISSQFEG
ACFLHEVRDR SEKQGLARLQ EILLSKILVI KDLRINNLFE GVNMHRHRLR YKKVLLVLDD
VDHIDQLEVL AQKREWFGSG SRIIITTKDK HLLVKHDVEK IYKMRTLSDD ESLELFKQYA
FKKNHPTKKF EDLSAQVIKY TAGLPLALKV LGSFLYGRDL AEWRSEVERL KQIPEDEILR
KLEPSFTGLK SIDQKIFLDI ACFFTGKKKD SVTRVLESFN FSPIIGIKVL MEKSLITISE
GRILMHQLIQ EMGWHIVRRE AFDYPRRYSR LWKSEDISHV LARNMGTEKI EGISLNLRKM
LTDISHALER NLGTEKIKGI PLNLTNVKEV NVSATAFMPM TRLRFLKIKN AYVSQSPDIL
PSELSWLSWH GYPSKSLPIS FQGERLVSLK LKNSRIIQLW KGSKVLGQLK YINLSHSHKL
IRTPDFSGTP NLERLVLEEC TSLVEINFSV GDLKKLVLLK LKNCINLKTL PKSIQLENLD
VLILSGCSKL KVFPEIEEEM NRLSELYLEA TAFSELPASV EKLSGVKVIN LSSCKNLESL
PNSIVRLKYL KELNVSKCSK LKSLPDDLGS LVSLEGLHCD DTPIQMIPST ISLLKNLKHL
SLRQCNALGL HVRSSISRES MGLVFSNLSG LCSLTMLDIG GCSISDGGIL CNLGFLPSLA
ELNLGGNTFT NISASSISGL TRLKVLQLVG CSRLEHFPEL PRAIEEVHAD ECISLKSIHQ
LAKYPTLRRL SLSQCHQLHD TDMVDALWSN MLKGLYVLRN DLSICIPGSQ IPMWFTYKNF
GENVTLTLAN NWYTDNLWGF AFCIVFERME WCGLYDGYLQ PSLGFPVNLK FKTYDGKEGD
IRSIIGIKGG DMSIRNSEHT LLAYVPSRRF LQPYNNEVYS PNDWIEIVAY STVQFDSKAW
GTRLVYLDDI IEA
//
