ID A0A1U7XRN3_NICSY Unreviewed; 637 AA.
AC A0A1U7XRN3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Ethylene response sensor 1 {ECO:0000313|RefSeq:XP_009794737.1, ECO:0000313|RefSeq:XP_009794738.1};
GN Name=LOC104241498 {ECO:0000313|RefSeq:XP_009794737.1,
GN ECO:0000313|RefSeq:XP_009794738.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009794737.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009794737.1, ECO:0000313|RefSeq:XP_009794738.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009794737.1,
RC ECO:0000313|RefSeq:XP_009794738.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000256|ARBA:ARBA00001935};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family.
CC {ECO:0000256|ARBA:ARBA00009842}.
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DR RefSeq; XP_009794737.1; XM_009796435.1.
DR RefSeq; XP_009794738.1; XM_009796436.1.
DR STRING; 4096.A0A1U7XRN3; -.
DR GeneID; 104241498; -.
DR KEGG; nsy:104241498; -.
DR eggNOG; KOG0519; Eukaryota.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051740; F:ethylene binding; IEA:UniProt.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0010105; P:negative regulation of ethylene-activated signaling pathway; IEA:UniProt.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR24423:SF625; ETHYLENE RESPONSE SENSOR 1; 1.
DR PANTHER; PTHR24423; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Ethylene signaling pathway {ECO:0000256|ARBA:ARBA00022745};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..588
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 637 AA; 71150 MW; DC1F43A3CDD61ED0 CRC64;
MMESCDCIEA LLPNDDLLVK YQYLSDFFIA FAYFSIPLEL IYFVHKSACF PYRWVLMQFG
AFIVLCGATH FISLWTFFMH SKTVAVVMTI AKILTAAVSC ITALMLVHII PDLLSVKTRE
LFLKARAEEL DKEMGLIIRQ EETGRHVRML THEIRSTLDR HTILKTTLVE LGRTLDLAEC
ALWMPCQGGL NLQLSHNLNN LLPLGSTVPI NLPIINEIFS SPGAIQIPHT NALARMRNTA
GRYIPPEVVA VRVPLLHLSN FHINDWPELS TKSYAVMVLI LPMNGLRKWR DHELELVQVV
ADQVAVALSH AAILEESMRA HDQLMEQNIA LDVARQEAEM AIRARNDFLA VMNHEMRTPM
HAVIALCSLL LETDLTPEQR VMIETILKSS NLLATLINDV LDLSRLEDGI LELENGTFNL
HGILREAVNL IKPIASLKKL SITLALALDL PILAVGDAKR LIQTLLNVAG NAVKFTKEGH
ISIEASVAKP EYARDCHPPE VYPMPSDGQF YLRVQVRDTG CGISPQDIPL VFTKFAEART
TSNRSSGGEG LGLAICRRFI QLMKGNIWIE SEGLGKGTTI TFVVKLGVCN HPNALPLLPM
APRGRLNQGS DDLFRYRQFR GDDGGMVGTV QRYQRSL
//
